Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis

<i>Background and Objectives:</i> Some of the postoperative complications following orthopaedic surgeries are associated with a systemic inflammatory response (SIR), which varies depending on the anaesthetic technique. We aimed to compare the effects of general and spinal anaesthesia on...

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Autores principales:	Ha-Jung Kim, Priodarshi Roychoudhury, Stuti Lohia, Jin-Sun Kim, Hyung-Tae Kim, Young-Jin Ro, Won-Uk Koh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	C-reactive protein general anaesthesia inflammation neutrophil-lymphocyte ratio platelet-lymphocyte ratio spinal anaesthesia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f76a6a1a474f487a84291be0558355a4
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spelling	oai:doaj.org-article:f76a6a1a474f487a84291be0558355a42021-11-25T18:18:57ZComparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis10.3390/medicina571112501648-91441010-660Xhttps://doaj.org/article/f76a6a1a474f487a84291be0558355a42021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1250https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives:</i> Some of the postoperative complications following orthopaedic surgeries are associated with a systemic inflammatory response (SIR), which varies depending on the anaesthetic technique. We aimed to compare the effects of general and spinal anaesthesia on the SIR after total knee arthroplasty (TKA), based on C-reactive protein (CRP) levels, the platelet-lymphocyte ratio (PLR), and the neutrophil-lymphocyte ratio (NLR). <i>Materials and Methods:</i> Patients who underwent TKA between January 2014 and December 2018 were included. Electronic medical records of the patients were retrospectively reviewed and analysed. To reduce the impact of potential confounding factors, we performed propensity score matching according to the anaesthetic technique. <i>Results:</i> A total of 1311 TKA cases were analysed. After propensity score matching, the maximal CRP value and changes in CRP levels in the general anaesthesia group were higher than those in the spinal anaesthesia group. However, the maximal NLR and PLR and the changes in NLR and PLR were not different between the two groups. There were no differences in postoperative clinical outcomes. <i>Conclusion:</i> Spinal anaesthesia tended to induce a lower inflammatory response than general anaesthesia when considering CRP levels in patients undergoing TKA. However, the effects of anaesthetic techniques on the overall outcomes were not significant.Ha-Jung KimPriodarshi RoychoudhuryStuti LohiaJin-Sun KimHyung-Tae KimYoung-Jin RoWon-Uk KohMDPI AGarticleC-reactive proteingeneral anaesthesiainflammationneutrophil-lymphocyte ratioplatelet-lymphocyte ratiospinal anaesthesiaMedicine (General)R5-920ENMedicina, Vol 57, Iss 1250, p 1250 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	C-reactive protein general anaesthesia inflammation neutrophil-lymphocyte ratio platelet-lymphocyte ratio spinal anaesthesia Medicine (General) R5-920
spellingShingle	C-reactive protein general anaesthesia inflammation neutrophil-lymphocyte ratio platelet-lymphocyte ratio spinal anaesthesia Medicine (General) R5-920 Ha-Jung Kim Priodarshi Roychoudhury Stuti Lohia Jin-Sun Kim Hyung-Tae Kim Young-Jin Ro Won-Uk Koh Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis
description	<i>Background and Objectives:</i> Some of the postoperative complications following orthopaedic surgeries are associated with a systemic inflammatory response (SIR), which varies depending on the anaesthetic technique. We aimed to compare the effects of general and spinal anaesthesia on the SIR after total knee arthroplasty (TKA), based on C-reactive protein (CRP) levels, the platelet-lymphocyte ratio (PLR), and the neutrophil-lymphocyte ratio (NLR). <i>Materials and Methods:</i> Patients who underwent TKA between January 2014 and December 2018 were included. Electronic medical records of the patients were retrospectively reviewed and analysed. To reduce the impact of potential confounding factors, we performed propensity score matching according to the anaesthetic technique. <i>Results:</i> A total of 1311 TKA cases were analysed. After propensity score matching, the maximal CRP value and changes in CRP levels in the general anaesthesia group were higher than those in the spinal anaesthesia group. However, the maximal NLR and PLR and the changes in NLR and PLR were not different between the two groups. There were no differences in postoperative clinical outcomes. <i>Conclusion:</i> Spinal anaesthesia tended to induce a lower inflammatory response than general anaesthesia when considering CRP levels in patients undergoing TKA. However, the effects of anaesthetic techniques on the overall outcomes were not significant.
format	article
author	Ha-Jung Kim Priodarshi Roychoudhury Stuti Lohia Jin-Sun Kim Hyung-Tae Kim Young-Jin Ro Won-Uk Koh
author_facet	Ha-Jung Kim Priodarshi Roychoudhury Stuti Lohia Jin-Sun Kim Hyung-Tae Kim Young-Jin Ro Won-Uk Koh
author_sort	Ha-Jung Kim
title	Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis
title_short	Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis
title_full	Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis
title_fullStr	Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis
title_full_unstemmed	Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis
title_sort	comparison of general and spinal anaesthesia on systemic inflammatory response in patients undergoing total knee arthroplasty: a propensity score matching analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f76a6a1a474f487a84291be0558355a4
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Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis

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