Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with the...

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Autores principales:	Simon Haworth, Chin Yang Shapland, Caroline Hayward, Bram P. Prins, Janine F. Felix, Carolina Medina-Gomez, Fernando Rivadeneira, Carol Wang, Tarunveer S. Ahluwalia, Martine Vrijheid, Mònica Guxens, Jordi Sunyer, Ioanna Tachmazidou, Klaudia Walter, Valentina Iotchkova, Andrew Jackson, Louise Cleal, Jennifer Huffmann, Josine L. Min, Lærke Sass, Paul R. H. J. Timmers, UK10K consortium, George Davey Smith, Simon E. Fisher, James F. Wilson, Tim J. Cole, Dietmar Fernandez-Orth, Klaus Bønnelykke, Hans Bisgaard, Craig E. Pennell, Vincent W. V. Jaddoe, George Dedoussis, Nicholas Timpson, Eleftheria Zeggini, Veronique Vitart, Beate St Pourcain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f76d0c11b2064d1e81bbe40dde812983
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spelling	oai:doaj.org-article:f76d0c11b2064d1e81bbe40dde8129832021-12-02T17:01:31ZLow-frequency variation in TP53 has large effects on head circumference and intracranial volume10.1038/s41467-018-07863-x2041-1723https://doaj.org/article/f76d0c11b2064d1e81bbe40dde8129832019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07863-xhttps://doaj.org/toc/2041-1723Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.Simon HaworthChin Yang ShaplandCaroline HaywardBram P. PrinsJanine F. FelixCarolina Medina-GomezFernando RivadeneiraCarol WangTarunveer S. AhluwaliaMartine VrijheidMònica GuxensJordi SunyerIoanna TachmazidouKlaudia WalterValentina IotchkovaAndrew JacksonLouise ClealJennifer HuffmannJosine L. MinLærke SassPaul R. H. J. TimmersUK10K consortiumGeorge Davey SmithSimon E. FisherJames F. WilsonTim J. ColeDietmar Fernandez-OrthKlaus BønnelykkeHans BisgaardCraig E. PennellVincent W. V. JaddoeGeorge DedoussisNicholas TimpsonEleftheria ZegginiVeronique VitartBeate St PourcainNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon Haworth Chin Yang Shapland Caroline Hayward Bram P. Prins Janine F. Felix Carolina Medina-Gomez Fernando Rivadeneira Carol Wang Tarunveer S. Ahluwalia Martine Vrijheid Mònica Guxens Jordi Sunyer Ioanna Tachmazidou Klaudia Walter Valentina Iotchkova Andrew Jackson Louise Cleal Jennifer Huffmann Josine L. Min Lærke Sass Paul R. H. J. Timmers UK10K consortium George Davey Smith Simon E. Fisher James F. Wilson Tim J. Cole Dietmar Fernandez-Orth Klaus Bønnelykke Hans Bisgaard Craig E. Pennell Vincent W. V. Jaddoe George Dedoussis Nicholas Timpson Eleftheria Zeggini Veronique Vitart Beate St Pourcain Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
description	Size and shape of the brain are, among others, influenced by the dimensions of the skull. Here, the authors report genome-wide association studies for head circumference and intracranial volume in children and adults and the identification of nine common or low-frequency variants associated with these traits.
format	article
author	Simon Haworth Chin Yang Shapland Caroline Hayward Bram P. Prins Janine F. Felix Carolina Medina-Gomez Fernando Rivadeneira Carol Wang Tarunveer S. Ahluwalia Martine Vrijheid Mònica Guxens Jordi Sunyer Ioanna Tachmazidou Klaudia Walter Valentina Iotchkova Andrew Jackson Louise Cleal Jennifer Huffmann Josine L. Min Lærke Sass Paul R. H. J. Timmers UK10K consortium George Davey Smith Simon E. Fisher James F. Wilson Tim J. Cole Dietmar Fernandez-Orth Klaus Bønnelykke Hans Bisgaard Craig E. Pennell Vincent W. V. Jaddoe George Dedoussis Nicholas Timpson Eleftheria Zeggini Veronique Vitart Beate St Pourcain
author_facet	Simon Haworth Chin Yang Shapland Caroline Hayward Bram P. Prins Janine F. Felix Carolina Medina-Gomez Fernando Rivadeneira Carol Wang Tarunveer S. Ahluwalia Martine Vrijheid Mònica Guxens Jordi Sunyer Ioanna Tachmazidou Klaudia Walter Valentina Iotchkova Andrew Jackson Louise Cleal Jennifer Huffmann Josine L. Min Lærke Sass Paul R. H. J. Timmers UK10K consortium George Davey Smith Simon E. Fisher James F. Wilson Tim J. Cole Dietmar Fernandez-Orth Klaus Bønnelykke Hans Bisgaard Craig E. Pennell Vincent W. V. Jaddoe George Dedoussis Nicholas Timpson Eleftheria Zeggini Veronique Vitart Beate St Pourcain
author_sort	Simon Haworth
title	Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
title_short	Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
title_full	Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
title_fullStr	Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
title_full_unstemmed	Low-frequency variation in TP53 has large effects on head circumference and intracranial volume
title_sort	low-frequency variation in tp53 has large effects on head circumference and intracranial volume
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f76d0c11b2064d1e81bbe40dde812983
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Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

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