Thrombolytic Agents: Nanocarriers in Targeted Release

A thrombus, known as a blood clot, may form within the vascular system of the body and impede blood flow. Thrombosis is the most common underlying pathology of cardiovascular diseases, contributing to high morbidity and mortality. However, the main thrombolytic drugs (urokinase, streptokinase, etc.)...

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Autores principales: Minghua Shen, Yujiao Wang, Fan Hu, Linwen Lv, Kui Chen, Gengmei Xing
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Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/f76ee979d4a648bc935a5093c0960f3a
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spelling oai:doaj.org-article:f76ee979d4a648bc935a5093c0960f3a2021-11-25T18:27:10ZThrombolytic Agents: Nanocarriers in Targeted Release10.3390/molecules262267761420-3049https://doaj.org/article/f76ee979d4a648bc935a5093c0960f3a2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6776https://doaj.org/toc/1420-3049A thrombus, known as a blood clot, may form within the vascular system of the body and impede blood flow. Thrombosis is the most common underlying pathology of cardiovascular diseases, contributing to high morbidity and mortality. However, the main thrombolytic drugs (urokinase, streptokinase, etc.) have shortcomings, including a short half-life, serious side effects and a lack of targeting, that limit their clinical application. The use of nano-drug delivery systems is expected to address these problems and a variety of approaches, including biological and physical responsive systems, have been explored. In this report, recent advances in the development of targeted nano-drug delivery systems are thoroughly reviewed.Minghua ShenYujiao WangFan HuLinwen LvKui ChenGengmei XingMDPI AGarticlenano-drug delivery systembiological nano-drug delivery systemphysical responsive nano-drug delivery systemOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6776, p 6776 (2021)
institution DOAJ
collection DOAJ
language EN
topic nano-drug delivery system
biological nano-drug delivery system
physical responsive nano-drug delivery system
Organic chemistry
QD241-441
spellingShingle nano-drug delivery system
biological nano-drug delivery system
physical responsive nano-drug delivery system
Organic chemistry
QD241-441
Minghua Shen
Yujiao Wang
Fan Hu
Linwen Lv
Kui Chen
Gengmei Xing
Thrombolytic Agents: Nanocarriers in Targeted Release
description A thrombus, known as a blood clot, may form within the vascular system of the body and impede blood flow. Thrombosis is the most common underlying pathology of cardiovascular diseases, contributing to high morbidity and mortality. However, the main thrombolytic drugs (urokinase, streptokinase, etc.) have shortcomings, including a short half-life, serious side effects and a lack of targeting, that limit their clinical application. The use of nano-drug delivery systems is expected to address these problems and a variety of approaches, including biological and physical responsive systems, have been explored. In this report, recent advances in the development of targeted nano-drug delivery systems are thoroughly reviewed.
format article
author Minghua Shen
Yujiao Wang
Fan Hu
Linwen Lv
Kui Chen
Gengmei Xing
author_facet Minghua Shen
Yujiao Wang
Fan Hu
Linwen Lv
Kui Chen
Gengmei Xing
author_sort Minghua Shen
title Thrombolytic Agents: Nanocarriers in Targeted Release
title_short Thrombolytic Agents: Nanocarriers in Targeted Release
title_full Thrombolytic Agents: Nanocarriers in Targeted Release
title_fullStr Thrombolytic Agents: Nanocarriers in Targeted Release
title_full_unstemmed Thrombolytic Agents: Nanocarriers in Targeted Release
title_sort thrombolytic agents: nanocarriers in targeted release
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/f76ee979d4a648bc935a5093c0960f3a
work_keys_str_mv AT minghuashen thrombolyticagentsnanocarriersintargetedrelease
AT yujiaowang thrombolyticagentsnanocarriersintargetedrelease
AT fanhu thrombolyticagentsnanocarriersintargetedrelease
AT linwenlv thrombolyticagentsnanocarriersintargetedrelease
AT kuichen thrombolyticagentsnanocarriersintargetedrelease
AT gengmeixing thrombolyticagentsnanocarriersintargetedrelease
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