Yersinia pseudotuberculosis-derived adhesins

Around fifteen surface components referred to adhesins have been identified in Yersinia pseudotuberculosis combining primarily microbiological, molecular and genetic, as well as immunochemical and biophysical methods. Y. pseudotuberculosis-derived adhesins vary in structure and chemical composition...

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Autores principales:	A. A. Byvalov, I. V. Konyshev
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2019
Materias:	yersinia pseudotuberculosis adhesins receptor eukaryotic cell Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f76f0fc057924f97b917bf35a95575e0
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spelling	oai:doaj.org-article:f76f0fc057924f97b917bf35a95575e02021-11-22T07:09:53ZYersinia pseudotuberculosis-derived adhesins2220-76192313-739810.15789/2220-7619-2019-3-4-437-448https://doaj.org/article/f76f0fc057924f97b917bf35a95575e02019-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/752https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Around fifteen surface components referred to adhesins have been identified in Yersinia pseudotuberculosis combining primarily microbiological, molecular and genetic, as well as immunochemical and biophysical methods. Y. pseudotuberculosis-derived adhesins vary in structure and chemical composition but they are mainly presented by protein molecules. Some of them were shown to participate not only in adhesive but in other pathogen-related physiological functions in the host-parasite interplay. Adhesins can mediate bacterial adhesion to eukaryotic cell either directly or via the extracellular matrix components. These adhesion molecules are encoded by chromosomal DNA excepting YadA protein which gene is located in the calcium-dependence plasmid pYV common for pathogenic yersisniae. An optimum temperature for adhesin biosynthesis is located close to the body temperature of warm-blooded animals; however, at low temperature only invasin InvA, full-length smooth lipopolysaccharide and porin OmpF are produced in Y. pseudotuberculosis. Several adhesins (Psa, InvA) can be expressed at low pH (corresponds to intracellular content), thereby defining pathogenic yersiniae as facultative intracellular parasites. Three human Yersinia genus pathogens differ by ability to produce adhesins. Y. pseudotuberculosis adherence to host cells or extracellular matrix components is determined by a cumulative adhesion-based activity, which expression depends on chemical composition and physicochemical environmental conditions. It’s proposed that at the initial stage of infectious process adherence of Y. pseudotuberculosis to intestinal epithelium is mediated by InvA protein and “smooth” LPS form. These adhesins are produced in bacterial cells at low (lower than 30°С) temperature occurring in environment from which a pathogen invades into the host. At later stages of pathogenesis, after penetrating through intestinal epithelium, bacterial cells produce other adhesins, which promote survival and dissemination primarily into the mesenteric lymph nodes and, possibly, liver and spleen. At later stages of pathogenesis, after penetrating through intestinal epithelium, bacterial cells produce other adhesins, which promote survival and dissemination primarily into the mesenteric lymph nodes and, perhaps, liver and spleen. Qualitative and quantitative spectrum of Y. pseudotuberculosis adhesins is determined by environmental parameters (intercellular space, intracellular content within the diverse eukaryotic cells).A. A. ByvalovI. V. KonyshevSankt-Peterburg : NIIÈM imeni Pasteraarticleyersinia pseudotuberculosisadhesinsreceptoreukaryotic cellInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 9, Iss 3-4, Pp 437-448 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	yersinia pseudotuberculosis adhesins receptor eukaryotic cell Infectious and parasitic diseases RC109-216
spellingShingle	yersinia pseudotuberculosis adhesins receptor eukaryotic cell Infectious and parasitic diseases RC109-216 A. A. Byvalov I. V. Konyshev Yersinia pseudotuberculosis-derived adhesins
description	Around fifteen surface components referred to adhesins have been identified in Yersinia pseudotuberculosis combining primarily microbiological, molecular and genetic, as well as immunochemical and biophysical methods. Y. pseudotuberculosis-derived adhesins vary in structure and chemical composition but they are mainly presented by protein molecules. Some of them were shown to participate not only in adhesive but in other pathogen-related physiological functions in the host-parasite interplay. Adhesins can mediate bacterial adhesion to eukaryotic cell either directly or via the extracellular matrix components. These adhesion molecules are encoded by chromosomal DNA excepting YadA protein which gene is located in the calcium-dependence plasmid pYV common for pathogenic yersisniae. An optimum temperature for adhesin biosynthesis is located close to the body temperature of warm-blooded animals; however, at low temperature only invasin InvA, full-length smooth lipopolysaccharide and porin OmpF are produced in Y. pseudotuberculosis. Several adhesins (Psa, InvA) can be expressed at low pH (corresponds to intracellular content), thereby defining pathogenic yersiniae as facultative intracellular parasites. Three human Yersinia genus pathogens differ by ability to produce adhesins. Y. pseudotuberculosis adherence to host cells or extracellular matrix components is determined by a cumulative adhesion-based activity, which expression depends on chemical composition and physicochemical environmental conditions. It’s proposed that at the initial stage of infectious process adherence of Y. pseudotuberculosis to intestinal epithelium is mediated by InvA protein and “smooth” LPS form. These adhesins are produced in bacterial cells at low (lower than 30°С) temperature occurring in environment from which a pathogen invades into the host. At later stages of pathogenesis, after penetrating through intestinal epithelium, bacterial cells produce other adhesins, which promote survival and dissemination primarily into the mesenteric lymph nodes and, possibly, liver and spleen. At later stages of pathogenesis, after penetrating through intestinal epithelium, bacterial cells produce other adhesins, which promote survival and dissemination primarily into the mesenteric lymph nodes and, perhaps, liver and spleen. Qualitative and quantitative spectrum of Y. pseudotuberculosis adhesins is determined by environmental parameters (intercellular space, intracellular content within the diverse eukaryotic cells).
format	article
author	A. A. Byvalov I. V. Konyshev
author_facet	A. A. Byvalov I. V. Konyshev
author_sort	A. A. Byvalov
title	Yersinia pseudotuberculosis-derived adhesins
title_short	Yersinia pseudotuberculosis-derived adhesins
title_full	Yersinia pseudotuberculosis-derived adhesins
title_fullStr	Yersinia pseudotuberculosis-derived adhesins
title_full_unstemmed	Yersinia pseudotuberculosis-derived adhesins
title_sort	yersinia pseudotuberculosis-derived adhesins
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2019
url	https://doaj.org/article/f76f0fc057924f97b917bf35a95575e0
work_keys_str_mv	AT aabyvalov yersiniapseudotuberculosisderivedadhesins AT ivkonyshev yersiniapseudotuberculosisderivedadhesins
_version_	1718417955117596672

Yersinia pseudotuberculosis-derived adhesins

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