Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure

Abstract The COVID-19 pandemic has generated many concerns about cross-contamination risks, particularly in hospital settings and Intensive Care Units (ICU). Virus-laden aerosols produced by infected patients can propagate throughout ventilated rooms and put medical personnel entering them at risk....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cyril Crawford, Emmanuel Vanoli, Baptiste Decorde, Maxime Lancelot, Camille Duprat, Christophe Josserand, Jonathan Jilesen, Lila Bouadma, Jean-François Timsit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f76ff6a262264055805b93793f0203f4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f76ff6a262264055805b93793f0203f4
record_format	dspace
spelling	oai:doaj.org-article:f76ff6a262264055805b93793f0203f42021-12-02T17:51:28ZModeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure10.1038/s41598-021-91265-52045-2322https://doaj.org/article/f76ff6a262264055805b93793f0203f42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91265-5https://doaj.org/toc/2045-2322Abstract The COVID-19 pandemic has generated many concerns about cross-contamination risks, particularly in hospital settings and Intensive Care Units (ICU). Virus-laden aerosols produced by infected patients can propagate throughout ventilated rooms and put medical personnel entering them at risk. Experimental results found with a schlieren optical method have shown that the air flows generated by a cough and normal breathing were modified by the oxygenation technique used, especially when using High Flow Nasal Canulae, increasing the shedding of potentially infectious airborne particles. This study also uses a 3D Computational Fluid Dynamics model based on a Lattice Boltzmann Method to simulate the air flows as well as the movement of numerous airborne particles produced by a patient’s cough within an ICU room under negative pressure. The effects of different mitigation scenarii on the amount of aerosols potentially containing SARS-CoV-2 that are extracted through the ventilation system are investigated. Numerical results indicate that adequate bed orientation and additional air treatment unit positioning can increase by 40% the number of particles extracted and decrease by 25% the amount of particles deposited on surfaces 45s after shedding. This approach could help lay the grounds for a more comprehensive way to tackle contamination risks in hospitals, as the model can be seen as a proof of concept and be adapted to any room configuration.Cyril CrawfordEmmanuel VanoliBaptiste DecordeMaxime LancelotCamille DupratChristophe JosserandJonathan JilesenLila BouadmaJean-François TimsitNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cyril Crawford Emmanuel Vanoli Baptiste Decorde Maxime Lancelot Camille Duprat Christophe Josserand Jonathan Jilesen Lila Bouadma Jean-François Timsit Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure
description	Abstract The COVID-19 pandemic has generated many concerns about cross-contamination risks, particularly in hospital settings and Intensive Care Units (ICU). Virus-laden aerosols produced by infected patients can propagate throughout ventilated rooms and put medical personnel entering them at risk. Experimental results found with a schlieren optical method have shown that the air flows generated by a cough and normal breathing were modified by the oxygenation technique used, especially when using High Flow Nasal Canulae, increasing the shedding of potentially infectious airborne particles. This study also uses a 3D Computational Fluid Dynamics model based on a Lattice Boltzmann Method to simulate the air flows as well as the movement of numerous airborne particles produced by a patient’s cough within an ICU room under negative pressure. The effects of different mitigation scenarii on the amount of aerosols potentially containing SARS-CoV-2 that are extracted through the ventilation system are investigated. Numerical results indicate that adequate bed orientation and additional air treatment unit positioning can increase by 40% the number of particles extracted and decrease by 25% the amount of particles deposited on surfaces 45s after shedding. This approach could help lay the grounds for a more comprehensive way to tackle contamination risks in hospitals, as the model can be seen as a proof of concept and be adapted to any room configuration.
format	article
author	Cyril Crawford Emmanuel Vanoli Baptiste Decorde Maxime Lancelot Camille Duprat Christophe Josserand Jonathan Jilesen Lila Bouadma Jean-François Timsit
author_facet	Cyril Crawford Emmanuel Vanoli Baptiste Decorde Maxime Lancelot Camille Duprat Christophe Josserand Jonathan Jilesen Lila Bouadma Jean-François Timsit
author_sort	Cyril Crawford
title	Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure
title_short	Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure
title_full	Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure
title_fullStr	Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure
title_full_unstemmed	Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure
title_sort	modeling of aerosol transmission of airborne pathogens in icu rooms of covid-19 patients with acute respiratory failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f76ff6a262264055805b93793f0203f4
work_keys_str_mv	AT cyrilcrawford modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure AT emmanuelvanoli modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure AT baptistedecorde modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure AT maximelancelot modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure AT camilleduprat modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure AT christophejosserand modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure AT jonathanjilesen modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure AT lilabouadma modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure AT jeanfrancoistimsit modelingofaerosoltransmissionofairbornepathogensinicuroomsofcovid19patientswithacuterespiratoryfailure
_version_	1718379264190971904

Modeling of aerosol transmission of airborne pathogens in ICU rooms of COVID-19 patients with acute respiratory failure

Ejemplares similares