Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan

Background: Dermatophytes are the most common group of fungi causing fungal infections all over the world. They are classified into three main groups Trichophyton, Microsporum and Epidermophyton. Among these, Trichophyton has the highest prevalence rate (70-90%) as compared to the others. The globa...

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Autores principales:	Fatima Ismail, Abdul Ghani, Saba Akbar
Formato:	article
Lenguaje:	EN
Publicado:	Jinnah University for Women 2021
Materias:	Antifungal Drug Resistance, Azoles, Dermatomycosis, Filamentous fungi, Sensitive Phenotype, Sterol biosynthesis. Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f774315680114db0b9bb652e89de8c96
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spelling	oai:doaj.org-article:f774315680114db0b9bb652e89de8c962021-11-25T06:47:12ZEmergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan10.37962/jbas.v12i1.3482305-87222521-8573https://doaj.org/article/f774315680114db0b9bb652e89de8c962021-08-01T00:00:00Zhttp://jbas.juw.edu.pk/index.php/JBAS/article/view/348https://doaj.org/toc/2305-8722https://doaj.org/toc/2521-8573 Background: Dermatophytes are the most common group of fungi causing fungal infections all over the world. They are classified into three main groups Trichophyton, Microsporum and Epidermophyton. Among these, Trichophyton has the highest prevalence rate (70-90%) as compared to the others. The global emergence of fungal infections is varied due to the socio-economic conditions throughout the world. Developing countries, like Pakistan, are facing an increase in the number of dermatophytoses, including frequent relapses and treatment failures. Objectives: The study have been conducted to identify the emerging fungal species, the role of commonly available antifungals such as azoles including voriconazole, ketoconazole, fluconazole and amphotericin B were used to determine the drug resistance among these species. Methodology: Nine groups of dermatophytes and non-dermatophyte fungi isolated from the patients of tinea corporis, tinea cruris, tinea capitis and tinea pedis infections were analyzed for Phenotypic diversity, antifungal susceptibility and strains identification, was performed by cultural characteristics and microscopy. Results: Nine groups of isolated fungal strains were identified as Trichophyton interdigitale, Trichophyton mentagrophyte, Trichophyton rubrum amongst dermatophytes class and Aspergillus terreus, Aspergillus verisocolor, Aspergillus niger, Acretonium sordidulum and Acremonium sclerotigenum of non-dermatophytes class. Conclusion: The study revealed Trichophytone interdigitale group as more frequent dermatophytes. Whereas, among the antifungal drugs, fluconazole that targets the Erg 1 gene of ergosterol biosynthesis in fungi is less effective most common antifungal drugs available locally. Fatima IsmailAbdul GhaniSaba AkbarJinnah University for WomenarticleAntifungal Drug Resistance, Azoles, Dermatomycosis, Filamentous fungi, Sensitive Phenotype, Sterol biosynthesis.MedicineRBiology (General)QH301-705.5ENRADS Journal of Biological Research & Applied Science, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antifungal Drug Resistance, Azoles, Dermatomycosis, Filamentous fungi, Sensitive Phenotype, Sterol biosynthesis. Medicine R Biology (General) QH301-705.5
spellingShingle	Antifungal Drug Resistance, Azoles, Dermatomycosis, Filamentous fungi, Sensitive Phenotype, Sterol biosynthesis. Medicine R Biology (General) QH301-705.5 Fatima Ismail Abdul Ghani Saba Akbar Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan
description	Background: Dermatophytes are the most common group of fungi causing fungal infections all over the world. They are classified into three main groups Trichophyton, Microsporum and Epidermophyton. Among these, Trichophyton has the highest prevalence rate (70-90%) as compared to the others. The global emergence of fungal infections is varied due to the socio-economic conditions throughout the world. Developing countries, like Pakistan, are facing an increase in the number of dermatophytoses, including frequent relapses and treatment failures. Objectives: The study have been conducted to identify the emerging fungal species, the role of commonly available antifungals such as azoles including voriconazole, ketoconazole, fluconazole and amphotericin B were used to determine the drug resistance among these species. Methodology: Nine groups of dermatophytes and non-dermatophyte fungi isolated from the patients of tinea corporis, tinea cruris, tinea capitis and tinea pedis infections were analyzed for Phenotypic diversity, antifungal susceptibility and strains identification, was performed by cultural characteristics and microscopy. Results: Nine groups of isolated fungal strains were identified as Trichophyton interdigitale, Trichophyton mentagrophyte, Trichophyton rubrum amongst dermatophytes class and Aspergillus terreus, Aspergillus verisocolor, Aspergillus niger, Acretonium sordidulum and Acremonium sclerotigenum of non-dermatophytes class. Conclusion: The study revealed Trichophytone interdigitale group as more frequent dermatophytes. Whereas, among the antifungal drugs, fluconazole that targets the Erg 1 gene of ergosterol biosynthesis in fungi is less effective most common antifungal drugs available locally.
format	article
author	Fatima Ismail Abdul Ghani Saba Akbar
author_facet	Fatima Ismail Abdul Ghani Saba Akbar
author_sort	Fatima Ismail
title	Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan
title_short	Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan
title_full	Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan
title_fullStr	Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan
title_full_unstemmed	Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan
title_sort	emergence of antifungal azole resistance in the fungal strains of tinea corporis, tinea capitis, tinea cruris and tinea pedis from the locality of southern punjab, pakistan
publisher	Jinnah University for Women
publishDate	2021
url	https://doaj.org/article/f774315680114db0b9bb652e89de8c96
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Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan

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