Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study

Ana Souto-Garc&iacute;a,1,2 Ana Fern&aacute;ndez-Somoano,1,2 Teresa Pascual,3 Sara M &Aacute;lvarez-Avell&oacute;n,1,2 Adonina Tard&oacute;n1,21Molecular Epidemiolgy of Cancer Unit, University Institute of Oncology, University of Oviedo, Oviedo, Asturias, Spai...

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Autores principales:	Pascual T, Fern&aacute;ndez-Somoano A, Souto-Garc&iacute;a A, &Aacute;lvarez-Avell&oacute;n SM, Tard&oacute;n A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f7752930256a45a495e0d2d3f2546c3c
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spelling	oai:doaj.org-article:f7752930256a45a495e0d2d3f2546c3c2021-12-02T04:19:43ZAssociation of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study1179-2728https://doaj.org/article/f7752930256a45a495e0d2d3f2546c3c2012-11-01T00:00:00Zhttp://www.dovepress.com/association-of-p21-ser31arg-and-p53-arg72pro-polymorphisms-with-lung-c-a11586https://doaj.org/toc/1179-2728Ana Souto-Garc&iacute;a,1,2 Ana Fern&aacute;ndez-Somoano,1,2 Teresa Pascual,3 Sara M &Aacute;lvarez-Avell&oacute;n,1,2 Adonina Tard&oacute;n1,21Molecular Epidemiolgy of Cancer Unit, University Institute of Oncology, University of Oviedo, Oviedo, Asturias, Spain; 2Consortium for Research in Epidemiology and Public Health (CIBERESP), Spain; 3Pneumology Department, Cabue&ntilde;es Hospital, Gij&oacute;n, Asturias, SpainBackground: The aim of this study was to investigate how Ser31Arg polymorphisms in p21 may modify lung cancer susceptibility. Because p21 is the major downstream mediator of p53, we analyzed the combined effect of two polymorphisms, p21 Ser31Arg and TP53 Arg72Pro, to elucidate whether polymorphic variants determine the risk of lung cancer.Methods: This was designed as a hospital-based case-control study, and included 675 cases and 675 control subjects matched by ethnicity, gender, and age. Genotypes were determined by polymerase chain reaction restriction fragment length polymorphism, and multivariate unconditional logistic regression was performed to analyze the results.Results: Subjects who carried the p21 Ser31Arg allele had a higher risk of lung cancer (adjusted odds ratio [OR] 1.38; 95% confidence interval [CI] 0.99&ndash;2.03). This risk was increased in men aged younger than 55 years (adjusted OR 2.35; 95% CI 1.00&ndash;5.51). Smokers had an increased risk of lung cancer (adjusted OR 2.23; 95% CI 1.24&ndash;4.02). Men younger than 55 years carrying risk alleles for both genes (p21 Ser31Arg and TP53 Arg72Pro) had an increased risk (adjusted OR 5.78; 95% CI 1.38&ndash;24.19), as did smokers with both risk alleles (adjusted OR 4.52; 95% CI 1.52&ndash;13.50).Conclusion: The presence of both variant alleles increased the risk of developing lung cancer in men, particularly in smokers younger than 55 years.Keywords: molecular epidemiology, cell cycle, tobacco, susceptibility, oncologyPascual TFern&aacute;ndez-Somoano ASouto-Garc&iacute;a A&Aacute;lvarez-Avell&oacute;n SMTard&oacute;n ADove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol 2012, Iss default, Pp 69-78 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Pascual T Fern&aacute;ndez-Somoano A Souto-Garc&iacute;a A &Aacute;lvarez-Avell&oacute;n SM Tard&oacute;n A Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study
description	Ana Souto-Garc&iacute;a,1,2 Ana Fern&aacute;ndez-Somoano,1,2 Teresa Pascual,3 Sara M &Aacute;lvarez-Avell&oacute;n,1,2 Adonina Tard&oacute;n1,21Molecular Epidemiolgy of Cancer Unit, University Institute of Oncology, University of Oviedo, Oviedo, Asturias, Spain; 2Consortium for Research in Epidemiology and Public Health (CIBERESP), Spain; 3Pneumology Department, Cabue&ntilde;es Hospital, Gij&oacute;n, Asturias, SpainBackground: The aim of this study was to investigate how Ser31Arg polymorphisms in p21 may modify lung cancer susceptibility. Because p21 is the major downstream mediator of p53, we analyzed the combined effect of two polymorphisms, p21 Ser31Arg and TP53 Arg72Pro, to elucidate whether polymorphic variants determine the risk of lung cancer.Methods: This was designed as a hospital-based case-control study, and included 675 cases and 675 control subjects matched by ethnicity, gender, and age. Genotypes were determined by polymerase chain reaction restriction fragment length polymorphism, and multivariate unconditional logistic regression was performed to analyze the results.Results: Subjects who carried the p21 Ser31Arg allele had a higher risk of lung cancer (adjusted odds ratio [OR] 1.38; 95% confidence interval [CI] 0.99&ndash;2.03). This risk was increased in men aged younger than 55 years (adjusted OR 2.35; 95% CI 1.00&ndash;5.51). Smokers had an increased risk of lung cancer (adjusted OR 2.23; 95% CI 1.24&ndash;4.02). Men younger than 55 years carrying risk alleles for both genes (p21 Ser31Arg and TP53 Arg72Pro) had an increased risk (adjusted OR 5.78; 95% CI 1.38&ndash;24.19), as did smokers with both risk alleles (adjusted OR 4.52; 95% CI 1.52&ndash;13.50).Conclusion: The presence of both variant alleles increased the risk of developing lung cancer in men, particularly in smokers younger than 55 years.Keywords: molecular epidemiology, cell cycle, tobacco, susceptibility, oncology
format	article
author	Pascual T Fern&aacute;ndez-Somoano A Souto-Garc&iacute;a A &Aacute;lvarez-Avell&oacute;n SM Tard&oacute;n A
author_facet	Pascual T Fern&aacute;ndez-Somoano A Souto-Garc&iacute;a A &Aacute;lvarez-Avell&oacute;n SM Tard&oacute;n A
author_sort	Pascual T
title	Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study
title_short	Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study
title_full	Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study
title_fullStr	Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study
title_full_unstemmed	Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study
title_sort	association of p21 ser31arg and p53 arg72pro polymorphisms with lung cancer risk in capua study
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/f7752930256a45a495e0d2d3f2546c3c
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Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study

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