Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table

Hepatitis E caused by hepatitis E viruses of the genotype 3 (HEV-3) is a major health concern in industrialized countries and due to its zoonotic character requires a “One Health” approach to unravel routes and sources of transmission. Knowing the viral diversity present in reservoir hosts, i.e., pi...

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Autores principales:	Isabelle Vonlanthen-Specker, Roger Stephan, Xaver Sidler, Dominik Moor, Cornel Fraefel, Claudia Bachofen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatitis E virus one health subtyping Switzerland pig wild boar Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/f775b8338d2e489886f3284e10121477
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spelling	oai:doaj.org-article:f775b8338d2e489886f3284e101214772021-11-25T16:18:21ZGenetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table10.3390/ani111131772076-2615https://doaj.org/article/f775b8338d2e489886f3284e101214772021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3177https://doaj.org/toc/2076-2615Hepatitis E caused by hepatitis E viruses of the genotype 3 (HEV-3) is a major health concern in industrialized countries and due to its zoonotic character requires a “One Health” approach to unravel routes and sources of transmission. Knowing the viral diversity present in reservoir hosts, i.e., pigs but also wild boars, is an important prerequisite for molecular epidemiology. The aim of this study was to gain primary information on the diversity of HEV-3 subtypes present along the food chain in Switzerland, as well as the diversity within these subtypes. To this end, samples of domestic pigs from slaughterhouses and carcass collection points, as well as from hunted wild boars, were tested for HEV RNA and antibodies. HEV positive meat products were provided by food testing labs. The HEV subtypes were determined using Sanger and next generation sequencing. The genetic analyses confirmed the predominance of a Swiss-specific cluster within subtype HEV-3h in pigs, meat products, and wild boars. This cluster, which may result from local virus evolution due to the isolated Swiss pig industry, supports fast differentiation of domestic and imported infections with HEV.Isabelle Vonlanthen-SpeckerRoger StephanXaver SidlerDominik MoorCornel FraefelClaudia BachofenMDPI AGarticlehepatitis E virusone healthsubtypingSwitzerlandpigwild boarVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3177, p 3177 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis E virus one health subtyping Switzerland pig wild boar Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	hepatitis E virus one health subtyping Switzerland pig wild boar Veterinary medicine SF600-1100 Zoology QL1-991 Isabelle Vonlanthen-Specker Roger Stephan Xaver Sidler Dominik Moor Cornel Fraefel Claudia Bachofen Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table
description	Hepatitis E caused by hepatitis E viruses of the genotype 3 (HEV-3) is a major health concern in industrialized countries and due to its zoonotic character requires a “One Health” approach to unravel routes and sources of transmission. Knowing the viral diversity present in reservoir hosts, i.e., pigs but also wild boars, is an important prerequisite for molecular epidemiology. The aim of this study was to gain primary information on the diversity of HEV-3 subtypes present along the food chain in Switzerland, as well as the diversity within these subtypes. To this end, samples of domestic pigs from slaughterhouses and carcass collection points, as well as from hunted wild boars, were tested for HEV RNA and antibodies. HEV positive meat products were provided by food testing labs. The HEV subtypes were determined using Sanger and next generation sequencing. The genetic analyses confirmed the predominance of a Swiss-specific cluster within subtype HEV-3h in pigs, meat products, and wild boars. This cluster, which may result from local virus evolution due to the isolated Swiss pig industry, supports fast differentiation of domestic and imported infections with HEV.
format	article
author	Isabelle Vonlanthen-Specker Roger Stephan Xaver Sidler Dominik Moor Cornel Fraefel Claudia Bachofen
author_facet	Isabelle Vonlanthen-Specker Roger Stephan Xaver Sidler Dominik Moor Cornel Fraefel Claudia Bachofen
author_sort	Isabelle Vonlanthen-Specker
title	Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table
title_short	Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table
title_full	Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table
title_fullStr	Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table
title_full_unstemmed	Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table
title_sort	genetic diversity of hepatitis e virus type 3 in switzerland—from stable to table
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f775b8338d2e489886f3284e10121477
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Genetic Diversity of Hepatitis E Virus Type 3 in Switzerland—From Stable to Table

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