Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults

Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus,...

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Autores principales:	Wellington F. Rodrigues, Camila B. Miguel, Ferdinando Agostinho, Gabriela V. da Silva, Javier E. Lazo-Chica, Sandra M. Naressi Scapin, Marcelo H. Napimoga, Carlos A. Trindade-da-Silva, José E. Krieger, Alexandre da Costa Pereira, Carlo J. Freire Oliveira, Siomar de Castro Soares, Carlos Ueira-Vieira
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Pathology RB1-214
Acceso en línea:	https://doaj.org/article/f775ee1e89a5411ebe329168f779e136
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spelling	oai:doaj.org-article:f775ee1e89a5411ebe329168f779e1362021-11-29T00:56:10ZMetabolomic Evaluation of Chronic Periodontal Disease in Older Adults1466-186110.1155/2021/1796204https://doaj.org/article/f775ee1e89a5411ebe329168f779e1362021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1796204https://doaj.org/toc/1466-1861Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Research participants were selected from long-term institutions in Brazil. Participants were individuals aged 65 years or older, healthy, or with chronic periodontal disease. Gas chromatography/mass spectrometry was used to evaluate potential biomarkers in 120 crevicular fluid samples. We identified 969 metabolites in the individuals. Of these, 15 metabolites showed a variable importance with projection score>1 and were associated with periodontal disease. Further analysis showed that among the 15 metabolites, two (5-aminovaleric acid and serine, 3TMS derivative) were found at higher concentrations in the crevicular fluid, indicating their potential diagnostic power for periodontal disease in older adults. Our findings indicated that some metabolites are present at high concentrations in the crevicular fluid in older adults with periodontal disease and can be used as biomarkers of periodontal disease.Wellington F. RodriguesCamila B. MiguelFerdinando AgostinhoGabriela V. da SilvaJavier E. Lazo-ChicaSandra M. Naressi ScapinMarcelo H. NapimogaCarlos A. Trindade-da-SilvaJosé E. KriegerAlexandre da Costa PereiraCarlo J. Freire OliveiraSiomar de Castro SoaresCarlos Ueira-VieiraHindawi LimitedarticlePathologyRB1-214ENMediators of Inflammation, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214
spellingShingle	Pathology RB1-214 Wellington F. Rodrigues Camila B. Miguel Ferdinando Agostinho Gabriela V. da Silva Javier E. Lazo-Chica Sandra M. Naressi Scapin Marcelo H. Napimoga Carlos A. Trindade-da-Silva José E. Krieger Alexandre da Costa Pereira Carlo J. Freire Oliveira Siomar de Castro Soares Carlos Ueira-Vieira Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults
description	Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Research participants were selected from long-term institutions in Brazil. Participants were individuals aged 65 years or older, healthy, or with chronic periodontal disease. Gas chromatography/mass spectrometry was used to evaluate potential biomarkers in 120 crevicular fluid samples. We identified 969 metabolites in the individuals. Of these, 15 metabolites showed a variable importance with projection score>1 and were associated with periodontal disease. Further analysis showed that among the 15 metabolites, two (5-aminovaleric acid and serine, 3TMS derivative) were found at higher concentrations in the crevicular fluid, indicating their potential diagnostic power for periodontal disease in older adults. Our findings indicated that some metabolites are present at high concentrations in the crevicular fluid in older adults with periodontal disease and can be used as biomarkers of periodontal disease.
format	article
author	Wellington F. Rodrigues Camila B. Miguel Ferdinando Agostinho Gabriela V. da Silva Javier E. Lazo-Chica Sandra M. Naressi Scapin Marcelo H. Napimoga Carlos A. Trindade-da-Silva José E. Krieger Alexandre da Costa Pereira Carlo J. Freire Oliveira Siomar de Castro Soares Carlos Ueira-Vieira
author_facet	Wellington F. Rodrigues Camila B. Miguel Ferdinando Agostinho Gabriela V. da Silva Javier E. Lazo-Chica Sandra M. Naressi Scapin Marcelo H. Napimoga Carlos A. Trindade-da-Silva José E. Krieger Alexandre da Costa Pereira Carlo J. Freire Oliveira Siomar de Castro Soares Carlos Ueira-Vieira
author_sort	Wellington F. Rodrigues
title	Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults
title_short	Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults
title_full	Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults
title_fullStr	Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults
title_full_unstemmed	Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults
title_sort	metabolomic evaluation of chronic periodontal disease in older adults
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/f775ee1e89a5411ebe329168f779e136
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Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults

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