Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice

Context: Cinnamomum verum J. Presl. (Lauraceae) has a high number of polyphenols with insulin-like activity, increases glucose utilization in animal muscle, and might be beneficial for diabetic patients. Objective: This study evaluated the effectiveness of an ointment prepared from Cinnamomum verum...

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Autores principales:	Amin Daemi, Mahsa Lotfi, Mohammad Reza Farahpour, Ahmad Oryan, Sina Jangkhahe Ghayour, Ali Sonboli
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	antioxidant activity cinnamaldehyde insulin-like growth factor 1 glucose transporter-1 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f7799f6634944717b384af4b4eb1ff76
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spelling	oai:doaj.org-article:f7799f6634944717b384af4b4eb1ff762021-11-17T14:21:56ZTopical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice1388-02091744-511610.1080/13880209.2019.1687525https://doaj.org/article/f7799f6634944717b384af4b4eb1ff762019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1687525https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Cinnamomum verum J. Presl. (Lauraceae) has a high number of polyphenols with insulin-like activity, increases glucose utilization in animal muscle, and might be beneficial for diabetic patients. Objective: This study evaluated the effectiveness of an ointment prepared from Cinnamomum verum hydroethanolic extract on wound healing in diabetic mice. Materials and methods: A total of 54 male BALB/c mice were divided into three groups: (1) diabetic non-treated group mice that were treated with soft yellow paraffin, (2 and 3) mice that were treated with 5 and 10% C. verum. Two circular full-thickness excisional wounds were created in each mouse, and the trial lasted for 16 d following induction of the wound. Further evaluation was made on the wound contraction ratio, histopathology parameters and mRNA levels of cyclin D1, insulin-like growth factor 1 (IGF-1), glucose transporter-1 (GLUT-1), total antioxidant capacity, and malondialdehyde of granulation tissue contents. HPLC apparatus was utilized to identify the compounds. Results: The HPLC data for cinnamon hydroethanolic extract identified cinnamaldehyde (11.26%) and 2-hydroxyl cinnamaldehyde (6.7%) as the major components. A significant increase was observed in wound contraction ratio, fibroblast proliferation, collagen deposition, re-epithelialization and keratin biosynthesis in the C. verum-treated groups in comparison to the diabetic non-treated group (p < 0.05). The expression level of cyclin D1, IGF1, GLUT 1 and antioxidant capacity increased in the C. verum-treated groups in comparison to the diabetic non-treated group (p < 0.05). Conclusions: Topical administration of C. verum accelerated wound healing and can possibly be employed in treating the wounds of diabetic patients.Amin DaemiMahsa LotfiMohammad Reza FarahpourAhmad OryanSina Jangkhahe GhayourAli SonboliTaylor & Francis Grouparticleantioxidant activitycinnamaldehydeinsulin-like growth factor 1glucose transporter-1Therapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 799-806 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant activity cinnamaldehyde insulin-like growth factor 1 glucose transporter-1 Therapeutics. Pharmacology RM1-950
spellingShingle	antioxidant activity cinnamaldehyde insulin-like growth factor 1 glucose transporter-1 Therapeutics. Pharmacology RM1-950 Amin Daemi Mahsa Lotfi Mohammad Reza Farahpour Ahmad Oryan Sina Jangkhahe Ghayour Ali Sonboli Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice
description	Context: Cinnamomum verum J. Presl. (Lauraceae) has a high number of polyphenols with insulin-like activity, increases glucose utilization in animal muscle, and might be beneficial for diabetic patients. Objective: This study evaluated the effectiveness of an ointment prepared from Cinnamomum verum hydroethanolic extract on wound healing in diabetic mice. Materials and methods: A total of 54 male BALB/c mice were divided into three groups: (1) diabetic non-treated group mice that were treated with soft yellow paraffin, (2 and 3) mice that were treated with 5 and 10% C. verum. Two circular full-thickness excisional wounds were created in each mouse, and the trial lasted for 16 d following induction of the wound. Further evaluation was made on the wound contraction ratio, histopathology parameters and mRNA levels of cyclin D1, insulin-like growth factor 1 (IGF-1), glucose transporter-1 (GLUT-1), total antioxidant capacity, and malondialdehyde of granulation tissue contents. HPLC apparatus was utilized to identify the compounds. Results: The HPLC data for cinnamon hydroethanolic extract identified cinnamaldehyde (11.26%) and 2-hydroxyl cinnamaldehyde (6.7%) as the major components. A significant increase was observed in wound contraction ratio, fibroblast proliferation, collagen deposition, re-epithelialization and keratin biosynthesis in the C. verum-treated groups in comparison to the diabetic non-treated group (p < 0.05). The expression level of cyclin D1, IGF1, GLUT 1 and antioxidant capacity increased in the C. verum-treated groups in comparison to the diabetic non-treated group (p < 0.05). Conclusions: Topical administration of C. verum accelerated wound healing and can possibly be employed in treating the wounds of diabetic patients.
format	article
author	Amin Daemi Mahsa Lotfi Mohammad Reza Farahpour Ahmad Oryan Sina Jangkhahe Ghayour Ali Sonboli
author_facet	Amin Daemi Mahsa Lotfi Mohammad Reza Farahpour Ahmad Oryan Sina Jangkhahe Ghayour Ali Sonboli
author_sort	Amin Daemi
title	Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice
title_short	Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice
title_full	Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice
title_fullStr	Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice
title_full_unstemmed	Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice
title_sort	topical application of cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/f7799f6634944717b384af4b4eb1ff76
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Topical application of Cinnamomum hydroethanolic extract improves wound healing by enhancing re-epithelialization and keratin biosynthesis in streptozotocin-induced diabetic mice

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