From multi-omics integration towards novel genomic interaction networks to identify key cancer cell line characteristics

From multi-omics integration towards novel genomic interaction networks to identify key cancer cell line characteristics

Abstract Cancer is a complex disease where cancer cells express epigenetic and transcriptomic mechanisms to promote tumor initiation, progression, and survival. To extract relevant features from the 2019 Cancer Cell Line Encyclopedia (CCLE), a multi-layer nonnegative matrix factorization approach is...

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Autores principales: T. J. M. Kuijpers, J. C. S. Kleinjans, D. G. J. Jennen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/f77ae54171204d649e417f2c0fbed7de
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