Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons

The firing activity of ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) dopaminergic (DA) neurons is an important factor in shaping DA release and its role in motivated behavior. Dendrites in DA neurons are the main postsynaptic compartment and, along with cell body and axon ini...

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Autores principales:	Trinidad Montero, Rafael Ignacio Gatica, Navid Farassat, Rodrigo Meza, Cristian González-Cabrera, Jochen Roeper, Pablo Henny
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dopamine substantia nigra ventral tegmental area dendritic morphology firing properties neuronal tracing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f77c2c966d5d4dcd94bce9ed2b92ce06
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spelling	oai:doaj.org-article:f77c2c966d5d4dcd94bce9ed2b92ce062021-11-19T07:47:41ZDendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons1662-511010.3389/fncir.2021.769342https://doaj.org/article/f77c2c966d5d4dcd94bce9ed2b92ce062021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncir.2021.769342/fullhttps://doaj.org/toc/1662-5110The firing activity of ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) dopaminergic (DA) neurons is an important factor in shaping DA release and its role in motivated behavior. Dendrites in DA neurons are the main postsynaptic compartment and, along with cell body and axon initial segment, contribute to action potential generation and firing pattern. In this study, the organization of the dendritic domain in individual VTA and SNc DA neurons of adult male mice, and their relationship to in vivo spontaneous firing, are described. In comparison with dorsal VTA DA neurons, ventrally located VTA neurons (as measured by cell body location) possess a shorter total dendritic length and simpler dendritic architecture, and exhibit the most irregular in vivo firing patterns among DA neurons. In contrast, for DA neurons in the SNc, the higher irregularity of firing was related to a smaller dendritic domain, as measured by convex hull volumes. However, firing properties were also related to the specific regional distribution of the dendritic tree. Thus, VTA DA neurons with a larger extension of their dendritic tree within the parabrachial pigmented (PBP) nucleus fired more regularly compared with those with relatively more dendrites extending outside the PBP. For DA neurons in the SNc, enhanced firing irregularity was associated with a smaller proportion of dendrites penetrating the substantia nigra pars reticulata. These results suggest that differences in dendritic morphology contribute to the in vivo firing properties of individual DA neurons, and that the existence of region-specific synaptic connectivity rules that shape firing diversity.Trinidad MonteroRafael Ignacio GaticaNavid FarassatRodrigo MezaCristian González-CabreraJochen RoeperPablo HennyFrontiers Media S.A.articledopaminesubstantia nigraventral tegmental areadendritic morphologyfiring propertiesneuronal tracingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neural Circuits, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dopamine substantia nigra ventral tegmental area dendritic morphology firing properties neuronal tracing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	dopamine substantia nigra ventral tegmental area dendritic morphology firing properties neuronal tracing Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Trinidad Montero Rafael Ignacio Gatica Navid Farassat Rodrigo Meza Cristian González-Cabrera Jochen Roeper Pablo Henny Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
description	The firing activity of ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) dopaminergic (DA) neurons is an important factor in shaping DA release and its role in motivated behavior. Dendrites in DA neurons are the main postsynaptic compartment and, along with cell body and axon initial segment, contribute to action potential generation and firing pattern. In this study, the organization of the dendritic domain in individual VTA and SNc DA neurons of adult male mice, and their relationship to in vivo spontaneous firing, are described. In comparison with dorsal VTA DA neurons, ventrally located VTA neurons (as measured by cell body location) possess a shorter total dendritic length and simpler dendritic architecture, and exhibit the most irregular in vivo firing patterns among DA neurons. In contrast, for DA neurons in the SNc, the higher irregularity of firing was related to a smaller dendritic domain, as measured by convex hull volumes. However, firing properties were also related to the specific regional distribution of the dendritic tree. Thus, VTA DA neurons with a larger extension of their dendritic tree within the parabrachial pigmented (PBP) nucleus fired more regularly compared with those with relatively more dendrites extending outside the PBP. For DA neurons in the SNc, enhanced firing irregularity was associated with a smaller proportion of dendrites penetrating the substantia nigra pars reticulata. These results suggest that differences in dendritic morphology contribute to the in vivo firing properties of individual DA neurons, and that the existence of region-specific synaptic connectivity rules that shape firing diversity.
format	article
author	Trinidad Montero Rafael Ignacio Gatica Navid Farassat Rodrigo Meza Cristian González-Cabrera Jochen Roeper Pablo Henny
author_facet	Trinidad Montero Rafael Ignacio Gatica Navid Farassat Rodrigo Meza Cristian González-Cabrera Jochen Roeper Pablo Henny
author_sort	Trinidad Montero
title	Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
title_short	Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
title_full	Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
title_fullStr	Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
title_full_unstemmed	Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons
title_sort	dendritic architecture predicts in vivo firing pattern in mouse ventral tegmental area and substantia nigra dopaminergic neurons
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f77c2c966d5d4dcd94bce9ed2b92ce06
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Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons

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