Stimuli-responsive polymeric micelles for drug delivery and cancer therapy

Qing Zhou,1,* Li Zhang,2,* TieHong Yang,1 Hong Wu1 1Department of Pharmaceutical Analysis, School of Pharmacy, Air Force Military Medical University, Xi’an, People’s Republic of China; 2State Key Laboratory of Military Stomatology, Air Force Military Medical University, Xi&r...

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Autores principales:	Zhou Q, Zhang L, Yang T, Wu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Nanomedicine Polymeric micelles Stimuli-responsive Drug delivery Cancer therapy. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f77c56972f034d2dba60597147534148
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spelling	oai:doaj.org-article:f77c56972f034d2dba605971475341482021-12-02T01:28:36ZStimuli-responsive polymeric micelles for drug delivery and cancer therapy1178-2013https://doaj.org/article/f77c56972f034d2dba605971475341482018-05-01T00:00:00Zhttps://www.dovepress.com/stimuli-responsive-polymeric-micelles-for-drug-delivery-and-cancer-the-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Qing Zhou,1,* Li Zhang,2,* TieHong Yang,1 Hong Wu1 1Department of Pharmaceutical Analysis, School of Pharmacy, Air Force Military Medical University, Xi’an, People’s Republic of China; 2State Key Laboratory of Military Stomatology, Air Force Military Medical University, Xi’an, People’s Republic of China *These authors contributed equally to this work Abstract: Polymeric micelles (PMs) have been widely investigated as nanocarriers for drug delivery and cancer treatments due to their excellent physicochemical properties, drug loading and release capacities, facile preparation methods, biocompatibility, and tumor targetability. They can be easily engineered with various functional moieties to further improve their performance in terms of bioavailability, circulation time, tumor specificity, and anticancer activity. The stimuli-sensitive PMs capable of responding to various extra- and intracellular biological stimuli (eg, acidic pH, altered redox potential, and upregulated enzyme), as well as external artificial stimuli (eg, magnetic field, light, temperature, and ultrasound), are considered as “smart” nanocarriers for delivery of anticancer drugs and/or imaging agents for various therapeutic and diagnostic applications. In this article, the recent advances in the development of stimuli-responsive PMs for drug delivery, imaging, and cancer therapy are reviewed. The article covers the generalities of stimuli-responsive PMs with a focus on their major delivery strategies and newly emerging technologies/nanomaterials, discusses their drawbacks and limitations, and provides their future perspectives. Keywords: nanomedicine, polymeric micelles, stimuli-responsive, drug delivery, cancer therapyZhou QZhang LYang TWu HDove Medical PressarticleNanomedicinePolymeric micellesStimuli-responsiveDrug deliveryCancer therapy.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2921-2942 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanomedicine Polymeric micelles Stimuli-responsive Drug delivery Cancer therapy. Medicine (General) R5-920
spellingShingle	Nanomedicine Polymeric micelles Stimuli-responsive Drug delivery Cancer therapy. Medicine (General) R5-920 Zhou Q Zhang L Yang T Wu H Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
description	Qing Zhou,1,* Li Zhang,2,* TieHong Yang,1 Hong Wu1 1Department of Pharmaceutical Analysis, School of Pharmacy, Air Force Military Medical University, Xi’an, People’s Republic of China; 2State Key Laboratory of Military Stomatology, Air Force Military Medical University, Xi’an, People’s Republic of China *These authors contributed equally to this work Abstract: Polymeric micelles (PMs) have been widely investigated as nanocarriers for drug delivery and cancer treatments due to their excellent physicochemical properties, drug loading and release capacities, facile preparation methods, biocompatibility, and tumor targetability. They can be easily engineered with various functional moieties to further improve their performance in terms of bioavailability, circulation time, tumor specificity, and anticancer activity. The stimuli-sensitive PMs capable of responding to various extra- and intracellular biological stimuli (eg, acidic pH, altered redox potential, and upregulated enzyme), as well as external artificial stimuli (eg, magnetic field, light, temperature, and ultrasound), are considered as “smart” nanocarriers for delivery of anticancer drugs and/or imaging agents for various therapeutic and diagnostic applications. In this article, the recent advances in the development of stimuli-responsive PMs for drug delivery, imaging, and cancer therapy are reviewed. The article covers the generalities of stimuli-responsive PMs with a focus on their major delivery strategies and newly emerging technologies/nanomaterials, discusses their drawbacks and limitations, and provides their future perspectives. Keywords: nanomedicine, polymeric micelles, stimuli-responsive, drug delivery, cancer therapy
format	article
author	Zhou Q Zhang L Yang T Wu H
author_facet	Zhou Q Zhang L Yang T Wu H
author_sort	Zhou Q
title	Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
title_short	Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
title_full	Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
title_fullStr	Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
title_full_unstemmed	Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
title_sort	stimuli-responsive polymeric micelles for drug delivery and cancer therapy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/f77c56972f034d2dba60597147534148
work_keys_str_mv	AT zhouq stimuliresponsivepolymericmicellesfordrugdeliveryandcancertherapy AT zhangl stimuliresponsivepolymericmicellesfordrugdeliveryandcancertherapy AT yangt stimuliresponsivepolymericmicellesfordrugdeliveryandcancertherapy AT wuh stimuliresponsivepolymericmicellesfordrugdeliveryandcancertherapy
_version_	1718403112348155904

Stimuli-responsive polymeric micelles for drug delivery and cancer therapy

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