Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape

The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest that Dxz4, Firre, and megadomains are dispensable...

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Autores principales:	John E. Froberg, Stefan F. Pinter, Andrea J. Kriz, Teddy Jégu, Jeannie T. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f77d839a60d344f6adff030162be5749
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spelling	oai:doaj.org-article:f77d839a60d344f6adff030162be57492021-12-02T16:56:59ZMegadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape10.1038/s41467-018-07446-w2041-1723https://doaj.org/article/f77d839a60d344f6adff030162be57492018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07446-whttps://doaj.org/toc/2041-1723The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest that Dxz4, Firre, and megadomains are dispensable for Xi silencing and escape from X-inactivation.John E. FrobergStefan F. PinterAndrea J. KrizTeddy JéguJeannie T. LeeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John E. Froberg Stefan F. Pinter Andrea J. Kriz Teddy Jégu Jeannie T. Lee Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape
description	The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest that Dxz4, Firre, and megadomains are dispensable for Xi silencing and escape from X-inactivation.
format	article
author	John E. Froberg Stefan F. Pinter Andrea J. Kriz Teddy Jégu Jeannie T. Lee
author_facet	John E. Froberg Stefan F. Pinter Andrea J. Kriz Teddy Jégu Jeannie T. Lee
author_sort	John E. Froberg
title	Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape
title_short	Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape
title_full	Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape
title_fullStr	Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape
title_full_unstemmed	Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape
title_sort	megadomains and superloops form dynamically but are dispensable for x-chromosome inactivation and gene escape
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f77d839a60d344f6adff030162be5749
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Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape

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