Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis

Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It plays a vital role in health maintenance and disease prevention, and the congenital deficiency of IL-7 signaling leads to profound immunodefici...

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Autores principales:	Deng Chen, Ting-Xuan Tang, Hai Deng, Xiang-Ping Yang, Zhao-Hui Tang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	IL-7 immune cells generation differentiation survival homeostasis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f77ded4233ed4462a47e5db75ae0d9c4
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spelling	oai:doaj.org-article:f77ded4233ed4462a47e5db75ae0d9c42021-12-02T10:21:10ZInterleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis1664-322410.3389/fimmu.2021.747324https://doaj.org/article/f77ded4233ed4462a47e5db75ae0d9c42021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.747324/fullhttps://doaj.org/toc/1664-3224Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It plays a vital role in health maintenance and disease prevention, and the congenital deficiency of IL-7 signaling leads to profound immunodeficiency. IL-7 contributes to host defense by regulating the development and homeostasis of immune cells, including T lymphocytes, B lymphocytes, and natural killer (NK) cells. Clinical trials of recombinant IL-7 have demonstrated safety and potent immune reconstitution effects. In this article, we discuss IL-7 and its functions in immune cell development, drawing on a substantial body of knowledge regarding the biology of IL-7. We aim to answer some remaining questions about IL-7, providing insights essential for designing new strategies of immune intervention.Deng ChenTing-Xuan TangHai DengXiang-Ping YangZhao-Hui TangFrontiers Media S.A.articleIL-7immune cellsgenerationdifferentiationsurvivalhomeostasisImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IL-7 immune cells generation differentiation survival homeostasis Immunologic diseases. Allergy RC581-607
spellingShingle	IL-7 immune cells generation differentiation survival homeostasis Immunologic diseases. Allergy RC581-607 Deng Chen Ting-Xuan Tang Hai Deng Xiang-Ping Yang Zhao-Hui Tang Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis
description	Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It plays a vital role in health maintenance and disease prevention, and the congenital deficiency of IL-7 signaling leads to profound immunodeficiency. IL-7 contributes to host defense by regulating the development and homeostasis of immune cells, including T lymphocytes, B lymphocytes, and natural killer (NK) cells. Clinical trials of recombinant IL-7 have demonstrated safety and potent immune reconstitution effects. In this article, we discuss IL-7 and its functions in immune cell development, drawing on a substantial body of knowledge regarding the biology of IL-7. We aim to answer some remaining questions about IL-7, providing insights essential for designing new strategies of immune intervention.
format	article
author	Deng Chen Ting-Xuan Tang Hai Deng Xiang-Ping Yang Zhao-Hui Tang
author_facet	Deng Chen Ting-Xuan Tang Hai Deng Xiang-Ping Yang Zhao-Hui Tang
author_sort	Deng Chen
title	Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis
title_short	Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis
title_full	Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis
title_fullStr	Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis
title_full_unstemmed	Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis
title_sort	interleukin-7 biology and its effects on immune cells: mediator of generation, differentiation, survival, and homeostasis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f77ded4233ed4462a47e5db75ae0d9c4
work_keys_str_mv	AT dengchen interleukin7biologyanditseffectsonimmunecellsmediatorofgenerationdifferentiationsurvivalandhomeostasis AT tingxuantang interleukin7biologyanditseffectsonimmunecellsmediatorofgenerationdifferentiationsurvivalandhomeostasis AT haideng interleukin7biologyanditseffectsonimmunecellsmediatorofgenerationdifferentiationsurvivalandhomeostasis AT xiangpingyang interleukin7biologyanditseffectsonimmunecellsmediatorofgenerationdifferentiationsurvivalandhomeostasis AT zhaohuitang interleukin7biologyanditseffectsonimmunecellsmediatorofgenerationdifferentiationsurvivalandhomeostasis
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Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis

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