Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus

Abstract The impairment of cardiovascular autonomic control among the underdiagnosed complication of diabetes mellitus (DM) with a high prevalence rate of up to 60% in type 2 DM (T2DM). Cardiac autonomic neuropathy (CAN) is an independent risk factor for cardiovascular mortality, arrhythmia, silent...

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Autores principales:	Muhanad M. Dhumad, Farqad B. Hamdan, Mahmood S. Khudhair, Hisham Y. Al-Matubsi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f77f1cb1349b4a1f95dde5ea79ccff99
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spelling	oai:doaj.org-article:f77f1cb1349b4a1f95dde5ea79ccff992021-12-02T13:30:28ZCorrelation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus10.1038/s41598-021-80962-w2045-2322https://doaj.org/article/f77f1cb1349b4a1f95dde5ea79ccff992021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-80962-whttps://doaj.org/toc/2045-2322Abstract The impairment of cardiovascular autonomic control among the underdiagnosed complication of diabetes mellitus (DM) with a high prevalence rate of up to 60% in type 2 DM (T2DM). Cardiac autonomic neuropathy (CAN) is an independent risk factor for cardiovascular mortality, arrhythmia, silent ischemia, any major cardiovascular event, and heart failure. We aimed to evaluate cardiovascular autonomic activity by different physiological maneuvers, study risk factors for diabetic CAN including age, gender, duration of diabetes, body mass index (BMI), and glycemic control, and correlate CAN stage with risk factors. One hundred and forty-two T2DM patients consisted of 62 males and 80 females and 100 volunteers as a control sample. Cardiac autonomic functions were assessed by Ewing's tests. Glycated hemoglobin (HbA1c), body weight, height, body mass index (BMI), and waist-hip ratio (WHR) were also measured. Cardiovascular autonomic functions and Ewing scores were significantly different in people with diabetes when compared with control healthy subjects. Ewings test values and Ewing scores were significantly different between diabetics with and without CAN and within patients with different CAN staging. People with diabetes with CAN have a significantly longer duration of disease when compared to those without CAN. A strong association has been found between CAN severity and patient age, duration of disease, HbA1c severity, and the WHR (P < 0.001) but not with BMI. The duration of disease and HbA1c level appear to be associated with the development of CAN (P = 0.001 and P = 0.008, respectively). The poorer glycemic control and the longer the duration of the disease, the higher the prevalence of CAN in T2DM. Age, duration of disease, WHR, and HbA1c are well correlated with the severity of CAN. Parasympathetic impairment is more sensitive to the detection of autonomic dysfunctions than do sympathetic impairment.Muhanad M. DhumadFarqad B. HamdanMahmood S. KhudhairHisham Y. Al-MatubsiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhanad M. Dhumad Farqad B. Hamdan Mahmood S. Khudhair Hisham Y. Al-Matubsi Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus
description	Abstract The impairment of cardiovascular autonomic control among the underdiagnosed complication of diabetes mellitus (DM) with a high prevalence rate of up to 60% in type 2 DM (T2DM). Cardiac autonomic neuropathy (CAN) is an independent risk factor for cardiovascular mortality, arrhythmia, silent ischemia, any major cardiovascular event, and heart failure. We aimed to evaluate cardiovascular autonomic activity by different physiological maneuvers, study risk factors for diabetic CAN including age, gender, duration of diabetes, body mass index (BMI), and glycemic control, and correlate CAN stage with risk factors. One hundred and forty-two T2DM patients consisted of 62 males and 80 females and 100 volunteers as a control sample. Cardiac autonomic functions were assessed by Ewing's tests. Glycated hemoglobin (HbA1c), body weight, height, body mass index (BMI), and waist-hip ratio (WHR) were also measured. Cardiovascular autonomic functions and Ewing scores were significantly different in people with diabetes when compared with control healthy subjects. Ewings test values and Ewing scores were significantly different between diabetics with and without CAN and within patients with different CAN staging. People with diabetes with CAN have a significantly longer duration of disease when compared to those without CAN. A strong association has been found between CAN severity and patient age, duration of disease, HbA1c severity, and the WHR (P < 0.001) but not with BMI. The duration of disease and HbA1c level appear to be associated with the development of CAN (P = 0.001 and P = 0.008, respectively). The poorer glycemic control and the longer the duration of the disease, the higher the prevalence of CAN in T2DM. Age, duration of disease, WHR, and HbA1c are well correlated with the severity of CAN. Parasympathetic impairment is more sensitive to the detection of autonomic dysfunctions than do sympathetic impairment.
format	article
author	Muhanad M. Dhumad Farqad B. Hamdan Mahmood S. Khudhair Hisham Y. Al-Matubsi
author_facet	Muhanad M. Dhumad Farqad B. Hamdan Mahmood S. Khudhair Hisham Y. Al-Matubsi
author_sort	Muhanad M. Dhumad
title	Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus
title_short	Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus
title_full	Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus
title_fullStr	Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus
title_full_unstemmed	Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus
title_sort	correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type ii diabetes mellitus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f77f1cb1349b4a1f95dde5ea79ccff99
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Correlation of staging and risk factors with cardiovascular autonomic neuropathy in patients with type II diabetes mellitus

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