Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma

AIM: To monitor the prognosis of patients with lacrimal gland pleomorphic adenoma (LGPA) following surgical resection within the past 10y. The factors affecting patient prognosis are analyzed and the experience of surgical treatment is summarized. METHODS: In this retrospective, comparative case ser...

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Autores principales:	Rui Liu, Nan Wang, Hong Zhang, Xin Ge, Jian-Min Ma
Formato:	article
Lenguaje:	EN
Publicado:	Press of International Journal of Ophthalmology (IJO PRESS) 2021
Materias:	pleomorphic adenoma lacrimal gland malignant transformation treatment prognosis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f77fbd50e42945d68851b1382aba23c4
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spelling	oai:doaj.org-article:f77fbd50e42945d68851b1382aba23c42021-11-26T04:02:12ZClinical analysis of 109 cases of lacrimal gland pleomorphic adenoma2222-39592227-489810.18240/ijo.2021.12.07https://doaj.org/article/f77fbd50e42945d68851b1382aba23c42021-12-01T00:00:00Zhttp://ies.ijo.cn/en_publish/2021/12/20211207.pdfhttps://doaj.org/toc/2222-3959https://doaj.org/toc/2227-4898AIM: To monitor the prognosis of patients with lacrimal gland pleomorphic adenoma (LGPA) following surgical resection within the past 10y. The factors affecting patient prognosis are analyzed and the experience of surgical treatment is summarized. METHODS: In this retrospective, comparative case series, clinical records from 109 cases of LGPA treated chiefly at the same institution between November 2009 and May 2019 were reviewed. All 109 patients underwent surgery, histopathological examination, and imaging examination. For patients who underwent surgery for the first time, LGPA could be resected completely, including tumor and capsule tissues, using a surgical approach via the eyebrow arch or double eyelid crease. RESULTS: The ratio of males to females was 1:1.60, the ages ranged from 19 to 74 years old with a mean age of 43.64±13.07 years old, and the ratio of left to right eyes was 1:1.37. A total of 109 patients underwent surgical excision and five of these received radiotherapy after malignant transformation. Of these patients, 15 were lost to follow up within the April 1, 2020 deadline and 1 was diagnosed as a recurring pathology. The 5-year recurrence rate for 86 patients who underwent initial surgery was 7.27%. Single factor analysis revealed that the course of disease, bone destruction, invasion of surrounding tissues, tumor size, capsule integrity, and expression of Ki-67 were statistically significant (P<0.05). Binomial Logistic regression analysis showed that capsule integrity was a risk factor influencing recurrence (P=0.008). CONCLUSION: LGPA has a risk of recurrence and potential for malignant transformation. Complete removal of the tumor and capsule in the initial surgery is a key factor in preventing recurrence.Rui LiuNan WangHong ZhangXin GeJian-Min MaPress of International Journal of Ophthalmology (IJO PRESS)articlepleomorphic adenomalacrimal glandmalignant transformationtreatmentprognosisOphthalmologyRE1-994ENInternational Journal of Ophthalmology, Vol 14, Iss 12, Pp 1852-1857 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pleomorphic adenoma lacrimal gland malignant transformation treatment prognosis Ophthalmology RE1-994
spellingShingle	pleomorphic adenoma lacrimal gland malignant transformation treatment prognosis Ophthalmology RE1-994 Rui Liu Nan Wang Hong Zhang Xin Ge Jian-Min Ma Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma
description	AIM: To monitor the prognosis of patients with lacrimal gland pleomorphic adenoma (LGPA) following surgical resection within the past 10y. The factors affecting patient prognosis are analyzed and the experience of surgical treatment is summarized. METHODS: In this retrospective, comparative case series, clinical records from 109 cases of LGPA treated chiefly at the same institution between November 2009 and May 2019 were reviewed. All 109 patients underwent surgery, histopathological examination, and imaging examination. For patients who underwent surgery for the first time, LGPA could be resected completely, including tumor and capsule tissues, using a surgical approach via the eyebrow arch or double eyelid crease. RESULTS: The ratio of males to females was 1:1.60, the ages ranged from 19 to 74 years old with a mean age of 43.64±13.07 years old, and the ratio of left to right eyes was 1:1.37. A total of 109 patients underwent surgical excision and five of these received radiotherapy after malignant transformation. Of these patients, 15 were lost to follow up within the April 1, 2020 deadline and 1 was diagnosed as a recurring pathology. The 5-year recurrence rate for 86 patients who underwent initial surgery was 7.27%. Single factor analysis revealed that the course of disease, bone destruction, invasion of surrounding tissues, tumor size, capsule integrity, and expression of Ki-67 were statistically significant (P<0.05). Binomial Logistic regression analysis showed that capsule integrity was a risk factor influencing recurrence (P=0.008). CONCLUSION: LGPA has a risk of recurrence and potential for malignant transformation. Complete removal of the tumor and capsule in the initial surgery is a key factor in preventing recurrence.
format	article
author	Rui Liu Nan Wang Hong Zhang Xin Ge Jian-Min Ma
author_facet	Rui Liu Nan Wang Hong Zhang Xin Ge Jian-Min Ma
author_sort	Rui Liu
title	Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma
title_short	Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma
title_full	Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma
title_fullStr	Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma
title_full_unstemmed	Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma
title_sort	clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma
publisher	Press of International Journal of Ophthalmology (IJO PRESS)
publishDate	2021
url	https://doaj.org/article/f77fbd50e42945d68851b1382aba23c4
work_keys_str_mv	AT ruiliu clinicalanalysisof109casesoflacrimalglandpleomorphicadenoma AT nanwang clinicalanalysisof109casesoflacrimalglandpleomorphicadenoma AT hongzhang clinicalanalysisof109casesoflacrimalglandpleomorphicadenoma AT xinge clinicalanalysisof109casesoflacrimalglandpleomorphicadenoma AT jianminma clinicalanalysisof109casesoflacrimalglandpleomorphicadenoma
_version_	1718409941258076160

Clinical analysis of 109 cases of lacrimal gland pleomorphic adenoma

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