Intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage

Ismail Abdul-Salim,1 Zunaina Embong,1,2 Sonny-Teo Khairy-Shamel,1,2 Mohd-Noor Raja-Azmi,1,21Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia; 2Universiti Sains Malaysia Hospital, Jalan Raja Perempuan Zainab II, Kubang Kerian, MalaysiaAbstract: Herein, we report our...

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Autores principales:	Abdul-Salim I, Embong Z, ST&nbsp;Khairy-Shamel, Raja-Azmi MN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f7822c01fff14ce7892356258c284c16
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spelling	oai:doaj.org-article:f7822c01fff14ce7892356258c284c162021-12-02T04:46:57ZIntravitreal ranibizumab in treating extensive traumatic submacular hemorrhage1177-54671177-5483https://doaj.org/article/f7822c01fff14ce7892356258c284c162013-04-01T00:00:00Zhttp://www.dovepress.com/intravitreal-ranibizumab-in-treating-extensive-traumatic-submacular-he-a12694https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Ismail Abdul-Salim,1 Zunaina Embong,1,2 Sonny-Teo Khairy-Shamel,1,2 Mohd-Noor Raja-Azmi,1,21Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia; 2Universiti Sains Malaysia Hospital, Jalan Raja Perempuan Zainab II, Kubang Kerian, MalaysiaAbstract: Herein, we report our experience in treating extensive traumatic submacular hemorrhage with a single dose of intravitreal ranibizumab. A 23-year-old healthy Malay man presented with a progressive reduction of central vision in the left eye of 2 days’ duration following a history of blunt trauma. Visual acuity was reduced to counting fingers. Examination revealed infero-temporal subconjunctival hemorrhage, traumatic anterior uveitis, and an extensive submacular hemorrhage with suspicion of a choroidal rupture in the affected eye. He was initially treated conservatively with topical prednisolone acetate 1%. The subconjunctival hemorrhage and anterior uveitis resolved but his vision remained poor with minimal resolution of the submacular hemorrhage at 1 week follow-up (day 12 post-trauma). In view of the poor resolution of submacular hemorrhage, he was treated with a single dose of 0.5 mg intravitreal ranibizumab at day 20 post-trauma. At 4 weeks post-intravitreal ranibizumab, there was an improvement in visual acuity (from counting fingers to 6/45) and complete resolution of the submacular hemorrhage with presence of a choroidal rupture scar temporal to the fovea, which was not seen clearly at presentation due to obscuration by blood. His visual acuity further improved to 6/18 at 3 months post-trauma. Although this single case had a favorable outcome, a large population cohort study is needed to establish the effectiveness of intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage.Keywords: trauma, choroidal rupture scar, visual acuity, submacular hemorrhage, anterior uveitisAbdul-Salim IEmbong ZST&nbsp;Khairy-ShamelRaja-Azmi MNDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 703-706 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Abdul-Salim I Embong Z ST&nbsp;Khairy-Shamel Raja-Azmi MN Intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage
description	Ismail Abdul-Salim,1 Zunaina Embong,1,2 Sonny-Teo Khairy-Shamel,1,2 Mohd-Noor Raja-Azmi,1,21Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia; 2Universiti Sains Malaysia Hospital, Jalan Raja Perempuan Zainab II, Kubang Kerian, MalaysiaAbstract: Herein, we report our experience in treating extensive traumatic submacular hemorrhage with a single dose of intravitreal ranibizumab. A 23-year-old healthy Malay man presented with a progressive reduction of central vision in the left eye of 2 days’ duration following a history of blunt trauma. Visual acuity was reduced to counting fingers. Examination revealed infero-temporal subconjunctival hemorrhage, traumatic anterior uveitis, and an extensive submacular hemorrhage with suspicion of a choroidal rupture in the affected eye. He was initially treated conservatively with topical prednisolone acetate 1%. The subconjunctival hemorrhage and anterior uveitis resolved but his vision remained poor with minimal resolution of the submacular hemorrhage at 1 week follow-up (day 12 post-trauma). In view of the poor resolution of submacular hemorrhage, he was treated with a single dose of 0.5 mg intravitreal ranibizumab at day 20 post-trauma. At 4 weeks post-intravitreal ranibizumab, there was an improvement in visual acuity (from counting fingers to 6/45) and complete resolution of the submacular hemorrhage with presence of a choroidal rupture scar temporal to the fovea, which was not seen clearly at presentation due to obscuration by blood. His visual acuity further improved to 6/18 at 3 months post-trauma. Although this single case had a favorable outcome, a large population cohort study is needed to establish the effectiveness of intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage.Keywords: trauma, choroidal rupture scar, visual acuity, submacular hemorrhage, anterior uveitis
format	article
author	Abdul-Salim I Embong Z ST&nbsp;Khairy-Shamel Raja-Azmi MN
author_facet	Abdul-Salim I Embong Z ST&nbsp;Khairy-Shamel Raja-Azmi MN
author_sort	Abdul-Salim I
title	Intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage
title_short	Intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage
title_full	Intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage
title_fullStr	Intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage
title_full_unstemmed	Intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage
title_sort	intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f7822c01fff14ce7892356258c284c16
work_keys_str_mv	AT abdulsalimi intravitrealranibizumabintreatingextensivetraumaticsubmacularhemorrhage AT embongz intravitrealranibizumabintreatingextensivetraumaticsubmacularhemorrhage AT stampnbspkhairyshamel intravitrealranibizumabintreatingextensivetraumaticsubmacularhemorrhage AT rajaazmimn intravitrealranibizumabintreatingextensivetraumaticsubmacularhemorrhage
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Intravitreal ranibizumab in treating extensive traumatic submacular hemorrhage

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