Colorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series

Introduction Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), a disease which affects primarily the respiratory and gastrointestinal (GI) tracts. The lifetime risk of colorectal cancer (CRC) in patients with CF is approximately 5-10 times t...

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Autores principales:	Sunjay Devarajan, Benjamin Musher, James Abraham
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	colon cancer syndrome polyp colorectal cystic fibrosis colonoscopy Medicine R
Acceso en línea:	https://doaj.org/article/f789f43ef7c14f2f97926255c76aca55
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spelling	oai:doaj.org-article:f789f43ef7c14f2f97926255c76aca552021-11-14T06:50:29ZColorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series2783-243010.30476/acrr.2021.89837.1083https://doaj.org/article/f789f43ef7c14f2f97926255c76aca552021-03-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_47424_6cee0ecf9d7b203b7fa96761b2451ada.pdfhttps://doaj.org/toc/2783-2430Introduction Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), a disease which affects primarily the respiratory and gastrointestinal (GI) tracts. The lifetime risk of colorectal cancer (CRC) in patients with CF is approximately 5-10 times that of the general population. In 2018, the CF Foundation CRC Screening Task Force recommended initiating CRC screening in adults with CF at age 40. Case Presentations In this case series, we present three cases of females with CF younger than age 40 diagnosed with CRC with variable presentations and stages. We discuss the data supporting current CRC screening guidelines in CF in an effort to raise awareness among clinicians regarding young-onset CRC in this population. Furthermore, we aim for this case series to help drive further investigation into the mechanisms underlying CF-related CRC and to open the door to changes in current screening practices. Conclusion People with CF are at substantially higher risk of development of CRC relative to the general population. While current CRC screening practices advocate for earlier screening in this population compared to average-risk patients, this case series highlights potential limitations to current screening guidelines.Sunjay DevarajanBenjamin MusherJames AbrahamShiraz University of Medical Sciencesarticlecolon cancer syndromepolypcolorectalcystic fibrosiscolonoscopyMedicineRENIranian Journal of Colorectal Research, Vol 9, Iss 1, Pp 40-43 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colon cancer syndrome polyp colorectal cystic fibrosis colonoscopy Medicine R
spellingShingle	colon cancer syndrome polyp colorectal cystic fibrosis colonoscopy Medicine R Sunjay Devarajan Benjamin Musher James Abraham Colorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series
description	Introduction Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), a disease which affects primarily the respiratory and gastrointestinal (GI) tracts. The lifetime risk of colorectal cancer (CRC) in patients with CF is approximately 5-10 times that of the general population. In 2018, the CF Foundation CRC Screening Task Force recommended initiating CRC screening in adults with CF at age 40. Case Presentations In this case series, we present three cases of females with CF younger than age 40 diagnosed with CRC with variable presentations and stages. We discuss the data supporting current CRC screening guidelines in CF in an effort to raise awareness among clinicians regarding young-onset CRC in this population. Furthermore, we aim for this case series to help drive further investigation into the mechanisms underlying CF-related CRC and to open the door to changes in current screening practices. Conclusion People with CF are at substantially higher risk of development of CRC relative to the general population. While current CRC screening practices advocate for earlier screening in this population compared to average-risk patients, this case series highlights potential limitations to current screening guidelines.
format	article
author	Sunjay Devarajan Benjamin Musher James Abraham
author_facet	Sunjay Devarajan Benjamin Musher James Abraham
author_sort	Sunjay Devarajan
title	Colorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series
title_short	Colorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series
title_full	Colorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series
title_fullStr	Colorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series
title_full_unstemmed	Colorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series
title_sort	colorectal cancer in people with cystic fibrosis under the age of 40: a case series
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/f789f43ef7c14f2f97926255c76aca55
work_keys_str_mv	AT sunjaydevarajan colorectalcancerinpeoplewithcysticfibrosisundertheageof40acaseseries AT benjaminmusher colorectalcancerinpeoplewithcysticfibrosisundertheageof40acaseseries AT jamesabraham colorectalcancerinpeoplewithcysticfibrosisundertheageof40acaseseries
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Colorectal Cancer in People with Cystic Fibrosis under the Age of 40: A Case Series

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