Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Effective chemotherapies against tuberculosis must kill the pathogen’s intracellular population. Here, Santucci et al. show that bacterial localisation within human macrophages impact pyrazinamide (PZA) accumulation and efficacy, and that combination with a second antibiotic (bedaquiline) enhances P...

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Autores principales:	Pierre Santucci, Daniel J. Greenwood, Antony Fearns, Kai Chen, Haibo Jiang, Maximiliano G. Gutierrez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f78b658f091740388c9796a7a5393a12
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spelling	oai:doaj.org-article:f78b658f091740388c9796a7a5393a122021-12-02T17:44:52ZIntracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide10.1038/s41467-021-24127-32041-1723https://doaj.org/article/f78b658f091740388c9796a7a5393a122021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24127-3https://doaj.org/toc/2041-1723Effective chemotherapies against tuberculosis must kill the pathogen’s intracellular population. Here, Santucci et al. show that bacterial localisation within human macrophages impact pyrazinamide (PZA) accumulation and efficacy, and that combination with a second antibiotic (bedaquiline) enhances PZA accumulation via a host-dependent process.Pierre SantucciDaniel J. GreenwoodAntony FearnsKai ChenHaibo JiangMaximiliano G. GutierrezNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre Santucci Daniel J. Greenwood Antony Fearns Kai Chen Haibo Jiang Maximiliano G. Gutierrez Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
description	Effective chemotherapies against tuberculosis must kill the pathogen’s intracellular population. Here, Santucci et al. show that bacterial localisation within human macrophages impact pyrazinamide (PZA) accumulation and efficacy, and that combination with a second antibiotic (bedaquiline) enhances PZA accumulation via a host-dependent process.
format	article
author	Pierre Santucci Daniel J. Greenwood Antony Fearns Kai Chen Haibo Jiang Maximiliano G. Gutierrez
author_facet	Pierre Santucci Daniel J. Greenwood Antony Fearns Kai Chen Haibo Jiang Maximiliano G. Gutierrez
author_sort	Pierre Santucci
title	Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
title_short	Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
title_full	Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
title_fullStr	Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
title_full_unstemmed	Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
title_sort	intracellular localisation of mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f78b658f091740388c9796a7a5393a12
work_keys_str_mv	AT pierresantucci intracellularlocalisationofmycobacteriumtuberculosisaffectsefficacyoftheantibioticpyrazinamide AT danieljgreenwood intracellularlocalisationofmycobacteriumtuberculosisaffectsefficacyoftheantibioticpyrazinamide AT antonyfearns intracellularlocalisationofmycobacteriumtuberculosisaffectsefficacyoftheantibioticpyrazinamide AT kaichen intracellularlocalisationofmycobacteriumtuberculosisaffectsefficacyoftheantibioticpyrazinamide AT haibojiang intracellularlocalisationofmycobacteriumtuberculosisaffectsefficacyoftheantibioticpyrazinamide AT maximilianoggutierrez intracellularlocalisationofmycobacteriumtuberculosisaffectsefficacyoftheantibioticpyrazinamide
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Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

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