Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex

Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex

Dan Shao,1,* Jing Li,1,* Fengying Guan,1 Yue Pan,1 Xuanang Xiao,1 Ming Zhang,1 Hong Zhang,2 Li Chen1,3 1Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, People’s Republic of China; 2Van’t Hoff Institute for Molecular Sciences,...

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Autores principales: Shao D, Li J, Guan F, Pan Y, Xiao X, Zhang M, Zhang H, Chen L
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/f78d0f4d01494ba2b949f14fa9080347
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spelling oai:doaj.org-article:f78d0f4d01494ba2b949f14fa90803472021-12-02T00:39:21ZSelective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex1178-2013https://doaj.org/article/f78d0f4d01494ba2b949f14fa90803472014-12-01T00:00:00Zhttp://www.dovepress.com/selective-inhibition-of-liver-cancer-growth-realized-by-the-intrinsic--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Dan Shao,1,* Jing Li,1,* Fengying Guan,1 Yue Pan,1 Xuanang Xiao,1 Ming Zhang,1 Hong Zhang,2 Li Chen1,3 1Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, People’s Republic of China; 2Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, the Netherlands; 3School of Nursing, Jilin University, Changchun, People’s Republic of China *These authors contributed equally to this work Abstract: Using the intrinsic toxicity of nanomaterials for anticancer therapy is an emerging concept. In this work, we discovered that CdTe/CdS quantum dots, when coated with lipids (QD-LC) instead of popular liposomes, polymers, or dendrimers, demonstrated extraordinarily high specificity for cancer cells, which was due to the difference in the macropinocytosis uptake pathways of QD-LC between the cancer cells and the normal cells. QD-LC-induced HepG2 cell apoptosis was concomitant with the activation of the JNK/caspase-3 signaling pathway. Moreover, QD-LC treatment resulted in a delay in the latent period for microtumor formation of mouse hepatocarcinoma H22 cells and inhibited tumor growth, with a reduction of 53.2% in tumor volume without toxicity in major organs after intratumoral administrations to tumor-bearing mice. Our results demonstrate that QD-LC could be a very promising theranostic agent against liver cancer. Keywords: CdTe/CdS quantum dot–lipid complex, intrinsic nanotoxicity, selectivity, liver cancer therapy, macropinocytosisShao DLi JGuan FPan YXiao XZhang MZhang HChen LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 5753-5769 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Shao D
Li J
Guan F
Pan Y
Xiao X
Zhang M
Zhang H
Chen L
Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex
description Dan Shao,1,* Jing Li,1,* Fengying Guan,1 Yue Pan,1 Xuanang Xiao,1 Ming Zhang,1 Hong Zhang,2 Li Chen1,3 1Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, People’s Republic of China; 2Van’t Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, the Netherlands; 3School of Nursing, Jilin University, Changchun, People’s Republic of China *These authors contributed equally to this work Abstract: Using the intrinsic toxicity of nanomaterials for anticancer therapy is an emerging concept. In this work, we discovered that CdTe/CdS quantum dots, when coated with lipids (QD-LC) instead of popular liposomes, polymers, or dendrimers, demonstrated extraordinarily high specificity for cancer cells, which was due to the difference in the macropinocytosis uptake pathways of QD-LC between the cancer cells and the normal cells. QD-LC-induced HepG2 cell apoptosis was concomitant with the activation of the JNK/caspase-3 signaling pathway. Moreover, QD-LC treatment resulted in a delay in the latent period for microtumor formation of mouse hepatocarcinoma H22 cells and inhibited tumor growth, with a reduction of 53.2% in tumor volume without toxicity in major organs after intratumoral administrations to tumor-bearing mice. Our results demonstrate that QD-LC could be a very promising theranostic agent against liver cancer. Keywords: CdTe/CdS quantum dot–lipid complex, intrinsic nanotoxicity, selectivity, liver cancer therapy, macropinocytosis
format article
author Shao D
Li J
Guan F
Pan Y
Xiao X
Zhang M
Zhang H
Chen L
author_facet Shao D
Li J
Guan F
Pan Y
Xiao X
Zhang M
Zhang H
Chen L
author_sort Shao D
title Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex
title_short Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex
title_full Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex
title_fullStr Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex
title_full_unstemmed Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex
title_sort selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot–lipid complex
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/f78d0f4d01494ba2b949f14fa9080347
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