Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis

Abstract Sepsis is the leading cause of acute kidney injury (AKI) and lung injury worldwide. Despite therapeutic advances, sepsis continues to be associated with high mortality. Because Brazilian green propolis (GP) has promising anti-inflammatory, antioxidant, and immunomodulatory properties, we hy...

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Autores principales:	Marcelo Augusto Duarte Silveira, José Manuel Condor Capcha, Talita Rojas Sanches, Roberto de Sousa Moreira, Margot S. Garnica, Maria Heloisa Shimizu, Andresa Berretta, Flávio Teles, Irene L. Noronha, Lúcia Andrade
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7924bf5dd5d4a32a3cbead01b528b22
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spelling	oai:doaj.org-article:f7924bf5dd5d4a32a3cbead01b528b222021-12-02T17:05:11ZGreen propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis10.1038/s41598-021-85124-62045-2322https://doaj.org/article/f7924bf5dd5d4a32a3cbead01b528b222021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85124-6https://doaj.org/toc/2045-2322Abstract Sepsis is the leading cause of acute kidney injury (AKI) and lung injury worldwide. Despite therapeutic advances, sepsis continues to be associated with high mortality. Because Brazilian green propolis (GP) has promising anti-inflammatory, antioxidant, and immunomodulatory properties, we hypothesized that it would protect kidneys and lungs in rats induced to sepsis by cecal ligation and puncture (CLP). Male Wistar rats were divided into groups—control (sham-operated); CLP (CLP only); and CLP + GP (CLP and treatment with GP at 6 h thereafter)—all receiving volume expansion and antibiotic therapy at 6 h after the procedures. By 24 h after the procedures, treatment with GP improved survival, attenuated sepsis-induced AKI, and restored renal tubular function. Whole-blood levels of reduced glutathione were higher in the CLP + GP group. Sepsis upregulated the Toll-like receptor 4/nuclear factor-kappa B axis in lung and renal tissues, as well as increasing inflammatory cytokine levels and macrophage infiltration; all of those effects were attenuated by GP. Treatment with GP decreased the numbers of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling-positive cells in renal and lung tissue, as well as protecting the morphology of the renal mitochondria. Our data open the prospect for clinical trials of the use of GP in sepsis.Marcelo Augusto Duarte SilveiraJosé Manuel Condor CapchaTalita Rojas SanchesRoberto de Sousa MoreiraMargot S. GarnicaMaria Heloisa ShimizuAndresa BerrettaFlávio TelesIrene L. NoronhaLúcia AndradeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcelo Augusto Duarte Silveira José Manuel Condor Capcha Talita Rojas Sanches Roberto de Sousa Moreira Margot S. Garnica Maria Heloisa Shimizu Andresa Berretta Flávio Teles Irene L. Noronha Lúcia Andrade Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
description	Abstract Sepsis is the leading cause of acute kidney injury (AKI) and lung injury worldwide. Despite therapeutic advances, sepsis continues to be associated with high mortality. Because Brazilian green propolis (GP) has promising anti-inflammatory, antioxidant, and immunomodulatory properties, we hypothesized that it would protect kidneys and lungs in rats induced to sepsis by cecal ligation and puncture (CLP). Male Wistar rats were divided into groups—control (sham-operated); CLP (CLP only); and CLP + GP (CLP and treatment with GP at 6 h thereafter)—all receiving volume expansion and antibiotic therapy at 6 h after the procedures. By 24 h after the procedures, treatment with GP improved survival, attenuated sepsis-induced AKI, and restored renal tubular function. Whole-blood levels of reduced glutathione were higher in the CLP + GP group. Sepsis upregulated the Toll-like receptor 4/nuclear factor-kappa B axis in lung and renal tissues, as well as increasing inflammatory cytokine levels and macrophage infiltration; all of those effects were attenuated by GP. Treatment with GP decreased the numbers of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling-positive cells in renal and lung tissue, as well as protecting the morphology of the renal mitochondria. Our data open the prospect for clinical trials of the use of GP in sepsis.
format	article
author	Marcelo Augusto Duarte Silveira José Manuel Condor Capcha Talita Rojas Sanches Roberto de Sousa Moreira Margot S. Garnica Maria Heloisa Shimizu Andresa Berretta Flávio Teles Irene L. Noronha Lúcia Andrade
author_facet	Marcelo Augusto Duarte Silveira José Manuel Condor Capcha Talita Rojas Sanches Roberto de Sousa Moreira Margot S. Garnica Maria Heloisa Shimizu Andresa Berretta Flávio Teles Irene L. Noronha Lúcia Andrade
author_sort	Marcelo Augusto Duarte Silveira
title	Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
title_short	Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
title_full	Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
title_fullStr	Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
title_full_unstemmed	Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
title_sort	green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7924bf5dd5d4a32a3cbead01b528b22
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_version_	1718381826951610368

Green propolis extract attenuates acute kidney injury and lung injury in a rat model of sepsis

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