The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis

Lysosome incorporate and degrade proteins in a process known as autophagy. There are three types of autophagy; macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Although autophagy is considered a nonselective degradation process, CMA is known as a selective degradation pathway....

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Autores principales:	Chieko Matsui, Putu Yuliandari, Lin Deng, Takayuki Abe, Ikuo Shoji
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hepatitis C virus chaperone-mediated autophagy CMA-targeting motif LAMP-2A HSC70 lysosome Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f79554a120c441cbacd54838bd166a19
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spelling	oai:doaj.org-article:f79554a120c441cbacd54838bd166a192021-12-02T09:33:04ZThe Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis2235-298810.3389/fcimb.2021.796664https://doaj.org/article/f79554a120c441cbacd54838bd166a192021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.796664/fullhttps://doaj.org/toc/2235-2988Lysosome incorporate and degrade proteins in a process known as autophagy. There are three types of autophagy; macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Although autophagy is considered a nonselective degradation process, CMA is known as a selective degradation pathway. All proteins internalized in the lysosome via CMA contain a pentapeptide KFERQ-motif, also known as a CMA-targeting motif, which is necessary for selectivity. CMA directly delivers a substrate protein into the lysosome lumen using the cytosolic chaperone HSC70 and the lysosomal receptor LAMP-2A for degradation. Hepatitis C virus (HCV) NS5A protein interacts with hepatocyte-nuclear factor 1α (HNF-1α) together with HSC70 and promotes the lysosomal degradation of HNF-1α via CMA, resulting in HCV-induced pathogenesis. HCV NS5A promotes recruitment of HSC70 to the substrate protein HNF-1α. HCV NS5A plays a crucial role in HCV-induced CMA. Further investigations of HCV NS5A-interacting proteins containing CMA-targeting motifs may help to elucidate HCV-induced pathogenesis.Chieko MatsuiPutu YuliandariPutu YuliandariLin DengTakayuki AbeIkuo ShojiFrontiers Media S.A.articlehepatitis C viruschaperone-mediated autophagyCMA-targeting motifLAMP-2AHSC70lysosomeMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis C virus chaperone-mediated autophagy CMA-targeting motif LAMP-2A HSC70 lysosome Microbiology QR1-502
spellingShingle	hepatitis C virus chaperone-mediated autophagy CMA-targeting motif LAMP-2A HSC70 lysosome Microbiology QR1-502 Chieko Matsui Putu Yuliandari Putu Yuliandari Lin Deng Takayuki Abe Ikuo Shoji The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis
description	Lysosome incorporate and degrade proteins in a process known as autophagy. There are three types of autophagy; macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Although autophagy is considered a nonselective degradation process, CMA is known as a selective degradation pathway. All proteins internalized in the lysosome via CMA contain a pentapeptide KFERQ-motif, also known as a CMA-targeting motif, which is necessary for selectivity. CMA directly delivers a substrate protein into the lysosome lumen using the cytosolic chaperone HSC70 and the lysosomal receptor LAMP-2A for degradation. Hepatitis C virus (HCV) NS5A protein interacts with hepatocyte-nuclear factor 1α (HNF-1α) together with HSC70 and promotes the lysosomal degradation of HNF-1α via CMA, resulting in HCV-induced pathogenesis. HCV NS5A promotes recruitment of HSC70 to the substrate protein HNF-1α. HCV NS5A plays a crucial role in HCV-induced CMA. Further investigations of HCV NS5A-interacting proteins containing CMA-targeting motifs may help to elucidate HCV-induced pathogenesis.
format	article
author	Chieko Matsui Putu Yuliandari Putu Yuliandari Lin Deng Takayuki Abe Ikuo Shoji
author_facet	Chieko Matsui Putu Yuliandari Putu Yuliandari Lin Deng Takayuki Abe Ikuo Shoji
author_sort	Chieko Matsui
title	The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis
title_short	The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis
title_full	The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis
title_fullStr	The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis
title_full_unstemmed	The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis
title_sort	role of chaperone-mediated autophagy in hepatitis c virus-induced pathogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f79554a120c441cbacd54838bd166a19
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The Role of Chaperone-Mediated Autophagy in Hepatitis C Virus-Induced Pathogenesis

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