PHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT

Pharmacotherapeutic efficiency of the dry extract from Lomatogonium carinthiacum in toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of tetracycline hydrochloride to Wistar white rats in the dose of 1.0 g/kg of the animal weight once a day for 7 days. The extract fr...

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Autores principales:	A. V. Fedorov, S. M. Nikolaev, Z. G. Sambuyeva, Y. G. Razuvaeva, A. A. Toropova, E. V. Ferubko
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2014
Materias:	lomatogonium carinthiacum (wulf.) reichenb extract hepatoprotective effect Science Q
Acceso en línea:	https://doaj.org/article/f795875f7f9e443287b45df841338ede
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spelling	oai:doaj.org-article:f795875f7f9e443287b45df841338ede2021-11-23T06:14:30ZPHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT2541-94202587-9596https://doaj.org/article/f795875f7f9e443287b45df841338ede2014-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1719https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Pharmacotherapeutic efficiency of the dry extract from Lomatogonium carinthiacum in toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of tetracycline hydrochloride to Wistar white rats in the dose of 1.0 g/kg of the animal weight once a day for 7 days. The extract from L. carinthiacum was administered per os in the dose of 100 mg/kg for 26 days. 1t has been established that the extract from L. carinthiacum has a marked hepatoprotective effect in the case of tetracycline hepatitis in white rats that is characterized by inhibition of the disturbances in choleretic and cholate-synthetic functions of the liver: the increase of bile secretion rate, preservation of cholate concentration in the bile, the decrease in the content of cholesterol triacylglycerides and alkaline phosphatase activity in the animal blood serum during the whole period of experiments. The tested remedy diminishes dystrophic and necrotic processes in hepatocytes, decreases the intensity of inflammatory infiltration in the liver and stimulates regeneration of liver cells in tetracycline hepatitis. The decrease of MDA content in the liver homogenate and increase in catalase activity against the same indices in control animals testify the marked antioxidant effect of L. carinthiacum.A. V. FedorovS. M. NikolaevZ. G. SambuyevaY. G. RazuvaevaA. A. ToropovaE. V. FerubkoScientific Сentre for Family Health and Human Reproduction Problemsarticlelomatogonium carinthiacum (wulf.) reichenblomatogonium carinthiacum (wulf.) reichenbextracthepatoprotective effectScienceQRUActa Biomedica Scientifica, Vol 0, Iss 1, Pp 79-83 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	lomatogonium carinthiacum (wulf.) reichenb lomatogonium carinthiacum (wulf.) reichenb extract hepatoprotective effect Science Q
spellingShingle	lomatogonium carinthiacum (wulf.) reichenb lomatogonium carinthiacum (wulf.) reichenb extract hepatoprotective effect Science Q A. V. Fedorov S. M. Nikolaev Z. G. Sambuyeva Y. G. Razuvaeva A. A. Toropova E. V. Ferubko PHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT
description	Pharmacotherapeutic efficiency of the dry extract from Lomatogonium carinthiacum in toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of tetracycline hydrochloride to Wistar white rats in the dose of 1.0 g/kg of the animal weight once a day for 7 days. The extract from L. carinthiacum was administered per os in the dose of 100 mg/kg for 26 days. 1t has been established that the extract from L. carinthiacum has a marked hepatoprotective effect in the case of tetracycline hepatitis in white rats that is characterized by inhibition of the disturbances in choleretic and cholate-synthetic functions of the liver: the increase of bile secretion rate, preservation of cholate concentration in the bile, the decrease in the content of cholesterol triacylglycerides and alkaline phosphatase activity in the animal blood serum during the whole period of experiments. The tested remedy diminishes dystrophic and necrotic processes in hepatocytes, decreases the intensity of inflammatory infiltration in the liver and stimulates regeneration of liver cells in tetracycline hepatitis. The decrease of MDA content in the liver homogenate and increase in catalase activity against the same indices in control animals testify the marked antioxidant effect of L. carinthiacum.
format	article
author	A. V. Fedorov S. M. Nikolaev Z. G. Sambuyeva Y. G. Razuvaeva A. A. Toropova E. V. Ferubko
author_facet	A. V. Fedorov S. M. Nikolaev Z. G. Sambuyeva Y. G. Razuvaeva A. A. Toropova E. V. Ferubko
author_sort	A. V. Fedorov
title	PHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT
title_short	PHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT
title_full	PHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT
title_fullStr	PHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT
title_full_unstemmed	PHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT
title_sort	pharmacotherapy of experimental hepatitis by lomatogonium carinthiacum extract
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2014
url	https://doaj.org/article/f795875f7f9e443287b45df841338ede
work_keys_str_mv	AT avfedorov pharmacotherapyofexperimentalhepatitisbylomatogoniumcarinthiacumextract AT smnikolaev pharmacotherapyofexperimentalhepatitisbylomatogoniumcarinthiacumextract AT zgsambuyeva pharmacotherapyofexperimentalhepatitisbylomatogoniumcarinthiacumextract AT ygrazuvaeva pharmacotherapyofexperimentalhepatitisbylomatogoniumcarinthiacumextract AT aatoropova pharmacotherapyofexperimentalhepatitisbylomatogoniumcarinthiacumextract AT evferubko pharmacotherapyofexperimentalhepatitisbylomatogoniumcarinthiacumextract
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PHARMACOTHERAPY OF EXPERIMENTAL HEPATITIS BY LOMATOGONIUM CARINTHIACUM EXTRACT

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