Structural basis of transcobalamin recognition by human CD320 receptor

Cellular uptake of vitamin B12 (cobalamin) requires the binding of holo-transcobalamin (TC) from plasma by CD320. Here, the authors report the structure of a complex between CD320 and TC loaded with cyanocobalamin, alongside additional functional analysis.

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Autores principales:	Amer Alam, Jae-Sung Woo, Jennifer Schmitz, Bernadette Prinz, Katharina Root, Fan Chen, Joël S. Bloch, Renato Zenobi, Kaspar P. Locher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7968f92215d4073a761f286014aedaa
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spelling	oai:doaj.org-article:f7968f92215d4073a761f286014aedaa2021-12-02T14:38:57ZStructural basis of transcobalamin recognition by human CD320 receptor10.1038/ncomms121002041-1723https://doaj.org/article/f7968f92215d4073a761f286014aedaa2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12100https://doaj.org/toc/2041-1723Cellular uptake of vitamin B12 (cobalamin) requires the binding of holo-transcobalamin (TC) from plasma by CD320. Here, the authors report the structure of a complex between CD320 and TC loaded with cyanocobalamin, alongside additional functional analysis.Amer AlamJae-Sung WooJennifer SchmitzBernadette PrinzKatharina RootFan ChenJoël S. BlochRenato ZenobiKaspar P. LocherNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amer Alam Jae-Sung Woo Jennifer Schmitz Bernadette Prinz Katharina Root Fan Chen Joël S. Bloch Renato Zenobi Kaspar P. Locher Structural basis of transcobalamin recognition by human CD320 receptor
description	Cellular uptake of vitamin B12 (cobalamin) requires the binding of holo-transcobalamin (TC) from plasma by CD320. Here, the authors report the structure of a complex between CD320 and TC loaded with cyanocobalamin, alongside additional functional analysis.
format	article
author	Amer Alam Jae-Sung Woo Jennifer Schmitz Bernadette Prinz Katharina Root Fan Chen Joël S. Bloch Renato Zenobi Kaspar P. Locher
author_facet	Amer Alam Jae-Sung Woo Jennifer Schmitz Bernadette Prinz Katharina Root Fan Chen Joël S. Bloch Renato Zenobi Kaspar P. Locher
author_sort	Amer Alam
title	Structural basis of transcobalamin recognition by human CD320 receptor
title_short	Structural basis of transcobalamin recognition by human CD320 receptor
title_full	Structural basis of transcobalamin recognition by human CD320 receptor
title_fullStr	Structural basis of transcobalamin recognition by human CD320 receptor
title_full_unstemmed	Structural basis of transcobalamin recognition by human CD320 receptor
title_sort	structural basis of transcobalamin recognition by human cd320 receptor
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f7968f92215d4073a761f286014aedaa
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_version_	1718390807938990080

Structural basis of transcobalamin recognition by human CD320 receptor

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