Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.

Acquired immune deficiency syndrome (AIDS) is a severe infectious disease that causes a large number of deaths every year. Traditional anti-AIDS drugs directly targeting the HIV-1 encoded enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) usually suffer from drug resistan...

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Autores principales: Bi-Qing Li, Bing Niu, Lei Chen, Ze-Jun Wei, Tao Huang, Min Jiang, Jing Lu, Ming-Yue Zheng, Xiang-Yin Kong, Yu-Dong Cai
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/f796dc65a99c4603a6af5389f0a3027c
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spelling oai:doaj.org-article:f796dc65a99c4603a6af5389f0a3027c2021-11-18T07:42:47ZIdentifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.1932-620310.1371/journal.pone.0065207https://doaj.org/article/f796dc65a99c4603a6af5389f0a3027c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762317/?tool=EBIhttps://doaj.org/toc/1932-6203Acquired immune deficiency syndrome (AIDS) is a severe infectious disease that causes a large number of deaths every year. Traditional anti-AIDS drugs directly targeting the HIV-1 encoded enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) usually suffer from drug resistance after a period of treatment and serious side effects. In recent years, the emergence of numerous useful information of protein-protein interactions (PPI) in the HIV life cycle and related inhibitors makes PPI a new way for antiviral drug intervention. In this study, we identified 26 core human proteins involved in PPI between HIV-1 and host, that have great potential for HIV therapy. In addition, 280 chemicals that interact with three HIV drugs targeting human proteins can also interact with these 26 core proteins. All these indicate that our method as presented in this paper is quite promising. The method may become a useful tool, or at least plays a complementary role to the existing method, for identifying novel anti-HIV drugs.Bi-Qing LiBing NiuLei ChenZe-Jun WeiTao HuangMin JiangJing LuMing-Yue ZhengXiang-Yin KongYu-Dong CaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65207 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Bi-Qing Li
Bing Niu
Lei Chen
Ze-Jun Wei
Tao Huang
Min Jiang
Jing Lu
Ming-Yue Zheng
Xiang-Yin Kong
Yu-Dong Cai
Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.
description Acquired immune deficiency syndrome (AIDS) is a severe infectious disease that causes a large number of deaths every year. Traditional anti-AIDS drugs directly targeting the HIV-1 encoded enzymes including reverse transcriptase (RT), protease (PR) and integrase (IN) usually suffer from drug resistance after a period of treatment and serious side effects. In recent years, the emergence of numerous useful information of protein-protein interactions (PPI) in the HIV life cycle and related inhibitors makes PPI a new way for antiviral drug intervention. In this study, we identified 26 core human proteins involved in PPI between HIV-1 and host, that have great potential for HIV therapy. In addition, 280 chemicals that interact with three HIV drugs targeting human proteins can also interact with these 26 core proteins. All these indicate that our method as presented in this paper is quite promising. The method may become a useful tool, or at least plays a complementary role to the existing method, for identifying novel anti-HIV drugs.
format article
author Bi-Qing Li
Bing Niu
Lei Chen
Ze-Jun Wei
Tao Huang
Min Jiang
Jing Lu
Ming-Yue Zheng
Xiang-Yin Kong
Yu-Dong Cai
author_facet Bi-Qing Li
Bing Niu
Lei Chen
Ze-Jun Wei
Tao Huang
Min Jiang
Jing Lu
Ming-Yue Zheng
Xiang-Yin Kong
Yu-Dong Cai
author_sort Bi-Qing Li
title Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.
title_short Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.
title_full Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.
title_fullStr Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.
title_full_unstemmed Identifying chemicals with potential therapy of HIV based on protein-protein and protein-chemical interaction network.
title_sort identifying chemicals with potential therapy of hiv based on protein-protein and protein-chemical interaction network.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/f796dc65a99c4603a6af5389f0a3027c
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