Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

LC3-associated phagocytosis (LAP) is a non-canonical use of the autophagy machinery that can contribute to immune responses. Here, the authors describe the mechanism by which ROS production regulates LAPosome stabilization sustaining MHC II dependent antigen presentation.

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Autores principales:	Laure-Anne Ligeon, Maria Pena-Francesch, Liliana Danusia Vanoaica, Nicolás Gonzalo Núñez, Deepti Talwar, Tobias P. Dick, Christian Münz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f797921446474bf6b04aaa690f425def
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spelling	oai:doaj.org-article:f797921446474bf6b04aaa690f425def2021-12-02T13:32:50ZOxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation10.1038/s41467-021-21829-62041-1723https://doaj.org/article/f797921446474bf6b04aaa690f425def2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21829-6https://doaj.org/toc/2041-1723LC3-associated phagocytosis (LAP) is a non-canonical use of the autophagy machinery that can contribute to immune responses. Here, the authors describe the mechanism by which ROS production regulates LAPosome stabilization sustaining MHC II dependent antigen presentation.Laure-Anne LigeonMaria Pena-FranceschLiliana Danusia VanoaicaNicolás Gonzalo NúñezDeepti TalwarTobias P. DickChristian MünzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laure-Anne Ligeon Maria Pena-Francesch Liliana Danusia Vanoaica Nicolás Gonzalo Núñez Deepti Talwar Tobias P. Dick Christian Münz Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation
description	LC3-associated phagocytosis (LAP) is a non-canonical use of the autophagy machinery that can contribute to immune responses. Here, the authors describe the mechanism by which ROS production regulates LAPosome stabilization sustaining MHC II dependent antigen presentation.
format	article
author	Laure-Anne Ligeon Maria Pena-Francesch Liliana Danusia Vanoaica Nicolás Gonzalo Núñez Deepti Talwar Tobias P. Dick Christian Münz
author_facet	Laure-Anne Ligeon Maria Pena-Francesch Liliana Danusia Vanoaica Nicolás Gonzalo Núñez Deepti Talwar Tobias P. Dick Christian Münz
author_sort	Laure-Anne Ligeon
title	Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation
title_short	Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation
title_full	Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation
title_fullStr	Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation
title_full_unstemmed	Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation
title_sort	oxidation inhibits autophagy protein deconjugation from phagosomes to sustain mhc class ii restricted antigen presentation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f797921446474bf6b04aaa690f425def
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Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation

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