Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

Detergents are indispensable reagents in membrane protein structural biology. Here, L. H. Urner and co-workers introduce oligoglycerol detergents (OGDs) and use native mass spectrometry to show how interactions of membrane proteins with native membrane lipids can be preserved during purification.

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Autores principales:	Leonhard H. Urner, Idlir Liko, Hsin-Yung Yen, Kin-Kuan Hoi, Jani Reddy Bolla, Joseph Gault, Fernando Gonçalves Almeida, Marc-Philip Schweder, Denis Shutin, Svenja Ehrmann, Rainer Haag, Carol V. Robinson, Kevin Pagel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f79c32473eac49729267ef98826a98bf
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spelling	oai:doaj.org-article:f79c32473eac49729267ef98826a98bf2021-12-02T14:41:14ZModular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors10.1038/s41467-020-14424-82041-1723https://doaj.org/article/f79c32473eac49729267ef98826a98bf2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14424-8https://doaj.org/toc/2041-1723Detergents are indispensable reagents in membrane protein structural biology. Here, L. H. Urner and co-workers introduce oligoglycerol detergents (OGDs) and use native mass spectrometry to show how interactions of membrane proteins with native membrane lipids can be preserved during purification.Leonhard H. UrnerIdlir LikoHsin-Yung YenKin-Kuan HoiJani Reddy BollaJoseph GaultFernando Gonçalves AlmeidaMarc-Philip SchwederDenis ShutinSvenja EhrmannRainer HaagCarol V. RobinsonKevin PagelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leonhard H. Urner Idlir Liko Hsin-Yung Yen Kin-Kuan Hoi Jani Reddy Bolla Joseph Gault Fernando Gonçalves Almeida Marc-Philip Schweder Denis Shutin Svenja Ehrmann Rainer Haag Carol V. Robinson Kevin Pagel Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
description	Detergents are indispensable reagents in membrane protein structural biology. Here, L. H. Urner and co-workers introduce oligoglycerol detergents (OGDs) and use native mass spectrometry to show how interactions of membrane proteins with native membrane lipids can be preserved during purification.
format	article
author	Leonhard H. Urner Idlir Liko Hsin-Yung Yen Kin-Kuan Hoi Jani Reddy Bolla Joseph Gault Fernando Gonçalves Almeida Marc-Philip Schweder Denis Shutin Svenja Ehrmann Rainer Haag Carol V. Robinson Kevin Pagel
author_facet	Leonhard H. Urner Idlir Liko Hsin-Yung Yen Kin-Kuan Hoi Jani Reddy Bolla Joseph Gault Fernando Gonçalves Almeida Marc-Philip Schweder Denis Shutin Svenja Ehrmann Rainer Haag Carol V. Robinson Kevin Pagel
author_sort	Leonhard H. Urner
title	Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
title_short	Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
title_full	Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
title_fullStr	Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
title_full_unstemmed	Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors
title_sort	modular detergents tailor the purification and structural analysis of membrane proteins including g-protein coupled receptors
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f79c32473eac49729267ef98826a98bf
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Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

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