Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

Detergents are indispensable reagents in membrane protein structural biology. Here, L. H. Urner and co-workers introduce oligoglycerol detergents (OGDs) and use native mass spectrometry to show how interactions of membrane proteins with native membrane lipids can be preserved during purification.

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Detalles Bibliográficos
Autores principales: Leonhard H. Urner, Idlir Liko, Hsin-Yung Yen, Kin-Kuan Hoi, Jani Reddy Bolla, Joseph Gault, Fernando Gonçalves Almeida, Marc-Philip Schweder, Denis Shutin, Svenja Ehrmann, Rainer Haag, Carol V. Robinson, Kevin Pagel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/f79c32473eac49729267ef98826a98bf
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https://doaj.org/article/f79c32473eac49729267ef98826a98bf

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