Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

Many tumors are known to be heterogeneous. Here, the authors examined multiple samples from 84 patients with lung adenocarcinoma and demonstrate that the intratumor heterogeneity of methylation and copy number associates with poor prognosis.

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Auteurs principaux:	Xing Hua, Wei Zhao, Angela C. Pesatori, Dario Consonni, Neil E. Caporaso, Tongwu Zhang, Bin Zhu, Mingyi Wang, Kristine Jones, Belynda Hicks, Lei Song, Joshua Sampson, David C. Wedge, Jianxin Shi, Maria Teresa Landi
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f79d02735f92481887e53a5ea22a061f
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spelling	oai:doaj.org-article:f79d02735f92481887e53a5ea22a061f2021-12-02T14:58:51ZGenetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma10.1038/s41467-020-16295-52041-1723https://doaj.org/article/f79d02735f92481887e53a5ea22a061f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16295-5https://doaj.org/toc/2041-1723Many tumors are known to be heterogeneous. Here, the authors examined multiple samples from 84 patients with lung adenocarcinoma and demonstrate that the intratumor heterogeneity of methylation and copy number associates with poor prognosis.Xing HuaWei ZhaoAngela C. PesatoriDario ConsonniNeil E. CaporasoTongwu ZhangBin ZhuMingyi WangKristine JonesBelynda HicksLei SongJoshua SampsonDavid C. WedgeJianxin ShiMaria Teresa LandiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xing Hua Wei Zhao Angela C. Pesatori Dario Consonni Neil E. Caporaso Tongwu Zhang Bin Zhu Mingyi Wang Kristine Jones Belynda Hicks Lei Song Joshua Sampson David C. Wedge Jianxin Shi Maria Teresa Landi Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
description	Many tumors are known to be heterogeneous. Here, the authors examined multiple samples from 84 patients with lung adenocarcinoma and demonstrate that the intratumor heterogeneity of methylation and copy number associates with poor prognosis.
format	article
author	Xing Hua Wei Zhao Angela C. Pesatori Dario Consonni Neil E. Caporaso Tongwu Zhang Bin Zhu Mingyi Wang Kristine Jones Belynda Hicks Lei Song Joshua Sampson David C. Wedge Jianxin Shi Maria Teresa Landi
author_facet	Xing Hua Wei Zhao Angela C. Pesatori Dario Consonni Neil E. Caporaso Tongwu Zhang Bin Zhu Mingyi Wang Kristine Jones Belynda Hicks Lei Song Joshua Sampson David C. Wedge Jianxin Shi Maria Teresa Landi
author_sort	Xing Hua
title	Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
title_short	Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
title_full	Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
title_fullStr	Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
title_full_unstemmed	Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
title_sort	genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f79d02735f92481887e53a5ea22a061f
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Genetic and epigenetic intratumor heterogeneity impacts prognosis of lung adenocarcinoma

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