Metabolic effects of acute thiamine depletion are reversed by rapamycin in breast and leukemia cells.

Thiamine-dependent enzymes (TDEs) control metabolic pathways that are frequently altered in cancer and therefore present cancer-relevant targets. We have previously shown that the recombinant enzyme thiaminase cleaves and depletes intracellular thiamine, has growth inhibitory activity against leukem...

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Autores principales: Shuqian Liu, Sumitra Miriyala, Mignon A Keaton, Craig T Jordan, Christina Wiedl, Daret K St Clair, Jeffrey A Moscow
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/f79d5967ecbf4b308fbfbda866487bd0
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