Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

Prime editors use a template sequence within their pegRNA to facilitate nucleotide substitutions or local indels. Here the authors use AAVs to deliver a split-intein prime editor in vivo to correct a pathogenic mutation.

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Detalles Bibliográficos
Autores principales:	Pengpeng Liu, Shun-Qing Liang, Chunwei Zheng, Esther Mintzer, Yan G. Zhao, Karthikeyan Ponnienselvan, Aamir Mir, Erik J. Sontheimer, Guangping Gao, Terence R. Flotte, Scot A. Wolfe, Wen Xue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f79d7d69ebf14bc9b101910fdc770c8c
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spelling	oai:doaj.org-article:f79d7d69ebf14bc9b101910fdc770c8c2021-12-02T18:15:35ZImproved prime editors enable pathogenic allele correction and cancer modelling in adult mice10.1038/s41467-021-22295-w2041-1723https://doaj.org/article/f79d7d69ebf14bc9b101910fdc770c8c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22295-whttps://doaj.org/toc/2041-1723Prime editors use a template sequence within their pegRNA to facilitate nucleotide substitutions or local indels. Here the authors use AAVs to deliver a split-intein prime editor in vivo to correct a pathogenic mutation.Pengpeng LiuShun-Qing LiangChunwei ZhengEsther MintzerYan G. ZhaoKarthikeyan PonnienselvanAamir MirErik J. SontheimerGuangping GaoTerence R. FlotteScot A. WolfeWen XueNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pengpeng Liu Shun-Qing Liang Chunwei Zheng Esther Mintzer Yan G. Zhao Karthikeyan Ponnienselvan Aamir Mir Erik J. Sontheimer Guangping Gao Terence R. Flotte Scot A. Wolfe Wen Xue Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
description	Prime editors use a template sequence within their pegRNA to facilitate nucleotide substitutions or local indels. Here the authors use AAVs to deliver a split-intein prime editor in vivo to correct a pathogenic mutation.
format	article
author	Pengpeng Liu Shun-Qing Liang Chunwei Zheng Esther Mintzer Yan G. Zhao Karthikeyan Ponnienselvan Aamir Mir Erik J. Sontheimer Guangping Gao Terence R. Flotte Scot A. Wolfe Wen Xue
author_facet	Pengpeng Liu Shun-Qing Liang Chunwei Zheng Esther Mintzer Yan G. Zhao Karthikeyan Ponnienselvan Aamir Mir Erik J. Sontheimer Guangping Gao Terence R. Flotte Scot A. Wolfe Wen Xue
author_sort	Pengpeng Liu
title	Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
title_short	Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
title_full	Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
title_fullStr	Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
title_full_unstemmed	Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
title_sort	improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f79d7d69ebf14bc9b101910fdc770c8c
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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

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