Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema

<h4>Purpose</h4> To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker. <h4>Methods</h4> 35 patients with mon...

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Autores principales:	Bo-Een Hwang, Mirinae Kim, Young-Hoon Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f79e39ffa3794a18abb32abd8b24ed40
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spelling	oai:doaj.org-article:f79e39ffa3794a18abb32abd8b24ed402021-11-04T06:07:18ZRole of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema1932-6203https://doaj.org/article/f79e39ffa3794a18abb32abd8b24ed402021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8530297/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4> To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker. <h4>Methods</h4> 35 patients with monocular BRVO and ME were analyzed retrospectively. Luminal and stromal areas in choroids of swept-source optical coherence tomography were calculated using the image binarization technique. The CVI was calculated as the ratio of the luminal to total choroidal area. The CVI of BRVO and ME eyes were compared with that of the unaffected fellow and post anti-vascular endothelial growth factor (VEGF) injected eyes. A regression analysis was performed on the choroidal parameters, logMAR visual acuity (VA) two years post disease onset and central macula thickness (CMT). <h4>Results</h4> The CVI of BRVO and ME eyes was significantly lower than the fellow and post-injected eyes (p<0.05). The regression analysis showed a strong association between two years after logMAR VA and the CVI of fellow eyes (R2 = 0.433, p<0.001). Remarkable correlations were observed in the CVI and subfoveal choroidal thickness of BRVO and ME eyes (R2 = 0.189, 0.155, respectively, p<0.05). The CMT of diseased eyes were also significantly associated with the CVI of unaffected fellow eyes (R2 = 0.113, p<0.05). <h4>Conclusions</h4> The alteration of CVI in BRVO and ME suggests that choroidal vasculature might be affected by extracellular fluid shift and VEGF changes. The fellow eye CVI could be a useful supplementary prognostic biomarker.Bo-Een HwangMirinae KimYoung-Hoon ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo-Een Hwang Mirinae Kim Young-Hoon Park Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema
description	<h4>Purpose</h4> To assess choroidal vasculature changes in eyes with branch retinal vein occlusion (BRVO) and macular edema (ME) using the choroidal vascularity index (CVI) and evaluate the effectiveness of CVI as a prognostic biomarker. <h4>Methods</h4> 35 patients with monocular BRVO and ME were analyzed retrospectively. Luminal and stromal areas in choroids of swept-source optical coherence tomography were calculated using the image binarization technique. The CVI was calculated as the ratio of the luminal to total choroidal area. The CVI of BRVO and ME eyes were compared with that of the unaffected fellow and post anti-vascular endothelial growth factor (VEGF) injected eyes. A regression analysis was performed on the choroidal parameters, logMAR visual acuity (VA) two years post disease onset and central macula thickness (CMT). <h4>Results</h4> The CVI of BRVO and ME eyes was significantly lower than the fellow and post-injected eyes (p<0.05). The regression analysis showed a strong association between two years after logMAR VA and the CVI of fellow eyes (R2 = 0.433, p<0.001). Remarkable correlations were observed in the CVI and subfoveal choroidal thickness of BRVO and ME eyes (R2 = 0.189, 0.155, respectively, p<0.05). The CMT of diseased eyes were also significantly associated with the CVI of unaffected fellow eyes (R2 = 0.113, p<0.05). <h4>Conclusions</h4> The alteration of CVI in BRVO and ME suggests that choroidal vasculature might be affected by extracellular fluid shift and VEGF changes. The fellow eye CVI could be a useful supplementary prognostic biomarker.
format	article
author	Bo-Een Hwang Mirinae Kim Young-Hoon Park
author_facet	Bo-Een Hwang Mirinae Kim Young-Hoon Park
author_sort	Bo-Een Hwang
title	Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema
title_short	Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema
title_full	Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema
title_fullStr	Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema
title_full_unstemmed	Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema
title_sort	role of the choroidal vascularity index in branch retinal vein occlusion (brvo) with macular edema
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f79e39ffa3794a18abb32abd8b24ed40
work_keys_str_mv	AT boeenhwang roleofthechoroidalvascularityindexinbranchretinalveinocclusionbrvowithmacularedema AT mirinaekim roleofthechoroidalvascularityindexinbranchretinalveinocclusionbrvowithmacularedema AT younghoonpark roleofthechoroidalvascularityindexinbranchretinalveinocclusionbrvowithmacularedema
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Role of the choroidal vascularity index in branch retinal vein occlusion (BRVO) with macular edema

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