Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer

Gastric cancer (GC) is one of the most common malignant tumors of digestive systems worldwide, with high recurrence and mortality. Chemotherapy is still the standard treatment option for GC and can effectively improve the survival and life quality of GC patients. However, with the emergence of drug...

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Autores principales:	Ying Liu, Xiang Ao, Guoqiang Ji, Yuan Zhang, Wanpeng Yu, Jianxun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	microRNA gastric cancer drug resistance biomarker therapeutic target Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f79ef5e217f1462d997767291a175cac
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spelling	oai:doaj.org-article:f79ef5e217f1462d997767291a175cac2021-12-01T13:58:13ZMechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer2234-943X10.3389/fonc.2021.768918https://doaj.org/article/f79ef5e217f1462d997767291a175cac2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.768918/fullhttps://doaj.org/toc/2234-943XGastric cancer (GC) is one of the most common malignant tumors of digestive systems worldwide, with high recurrence and mortality. Chemotherapy is still the standard treatment option for GC and can effectively improve the survival and life quality of GC patients. However, with the emergence of drug resistance, the clinical application of chemotherapeutic agents has been seriously restricted in GC patients. Although the mechanisms of drug resistance have been broadly investigated, they are still largely unknown. MicroRNAs (miRNAs) are a large group of small non-coding RNAs (ncRNAs) widely involved in the occurrence and progression of many cancer types, including GC. An increasing amount of evidence suggests that miRNAs may play crucial roles in the development of drug resistance by regulating some drug resistance-related proteins as well as gene expression. Some also exhibit great potential as novel biomarkers for predicting drug response to chemotherapy and therapeutic targets for GC patients. In this review, we systematically summarize recent advances in miRNAs and focus on their molecular mechanisms in the development of drug resistance in GC progression. We also highlight the potential of drug resistance-related miRNAs as biomarkers and therapeutic targets for GC patients.Ying LiuYing LiuXiang AoGuoqiang JiYuan ZhangWanpeng YuJianxun WangFrontiers Media S.A.articlemicroRNAgastric cancerdrug resistancebiomarkertherapeutic targetNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microRNA gastric cancer drug resistance biomarker therapeutic target Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	microRNA gastric cancer drug resistance biomarker therapeutic target Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ying Liu Ying Liu Xiang Ao Guoqiang Ji Yuan Zhang Wanpeng Yu Jianxun Wang Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer
description	Gastric cancer (GC) is one of the most common malignant tumors of digestive systems worldwide, with high recurrence and mortality. Chemotherapy is still the standard treatment option for GC and can effectively improve the survival and life quality of GC patients. However, with the emergence of drug resistance, the clinical application of chemotherapeutic agents has been seriously restricted in GC patients. Although the mechanisms of drug resistance have been broadly investigated, they are still largely unknown. MicroRNAs (miRNAs) are a large group of small non-coding RNAs (ncRNAs) widely involved in the occurrence and progression of many cancer types, including GC. An increasing amount of evidence suggests that miRNAs may play crucial roles in the development of drug resistance by regulating some drug resistance-related proteins as well as gene expression. Some also exhibit great potential as novel biomarkers for predicting drug response to chemotherapy and therapeutic targets for GC patients. In this review, we systematically summarize recent advances in miRNAs and focus on their molecular mechanisms in the development of drug resistance in GC progression. We also highlight the potential of drug resistance-related miRNAs as biomarkers and therapeutic targets for GC patients.
format	article
author	Ying Liu Ying Liu Xiang Ao Guoqiang Ji Yuan Zhang Wanpeng Yu Jianxun Wang
author_facet	Ying Liu Ying Liu Xiang Ao Guoqiang Ji Yuan Zhang Wanpeng Yu Jianxun Wang
author_sort	Ying Liu
title	Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer
title_short	Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer
title_full	Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer
title_fullStr	Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer
title_full_unstemmed	Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer
title_sort	mechanisms of action and clinical implications of micrornas in the drug resistance of gastric cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f79ef5e217f1462d997767291a175cac
work_keys_str_mv	AT yingliu mechanismsofactionandclinicalimplicationsofmicrornasinthedrugresistanceofgastriccancer AT yingliu mechanismsofactionandclinicalimplicationsofmicrornasinthedrugresistanceofgastriccancer AT xiangao mechanismsofactionandclinicalimplicationsofmicrornasinthedrugresistanceofgastriccancer AT guoqiangji mechanismsofactionandclinicalimplicationsofmicrornasinthedrugresistanceofgastriccancer AT yuanzhang mechanismsofactionandclinicalimplicationsofmicrornasinthedrugresistanceofgastriccancer AT wanpengyu mechanismsofactionandclinicalimplicationsofmicrornasinthedrugresistanceofgastriccancer AT jianxunwang mechanismsofactionandclinicalimplicationsofmicrornasinthedrugresistanceofgastriccancer
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Mechanisms of Action And Clinical Implications of MicroRNAs in the Drug Resistance of Gastric Cancer

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