Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum

Mohamed A Dkhil,1,2 Saleh Al-Quraishy,1 Rizwan Wahab11Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, EgyptAbstract: Nanomedicine has recently emerged as a better option for t...

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Autores principales:	Dkhil MA, Al-Quraishy S, Wahab R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f7a38283a0994678b74b812291976d02
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spelling	oai:doaj.org-article:f7a38283a0994678b74b812291976d022021-12-02T00:40:25ZAnticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum1178-2013https://doaj.org/article/f7a38283a0994678b74b812291976d022015-03-01T00:00:00Zhttp://www.dovepress.com/anticoccidial-and-antioxidant-activities-of-zinc-oxide-nanoparticles-o-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Mohamed A Dkhil,1,2 Saleh Al-Quraishy,1 Rizwan Wahab11Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, EgyptAbstract: Nanomedicine has recently emerged as a better option for the treatment of various diseases. Here, we investigated the in vivo anticoccidial properties of zinc oxide nanoparticles (ZNPs). ZNPs were crystalline in nature, with a smooth and spherical surface and a diameter in the range of ~10–15 nm. The X-ray diffraction pattern was utilized to identify the crystalline property of the grown ZNPs, whereas field emission scanning electron microscopy was employed to check the size and morphology of the ZNPs. The data showed that mice infected with Eimeria papillata produced 29.7×103±1,500 oocysts/g feces on day 5 postinfection. This output was significantly decreased, to 12.5×103±1,000 oocysts, in mice treated with ZNPs. Infection also induced inflammation and injury of the jejunum. This was evidenced (1) through an increase in the inflammatory histological score, (2) through increased production of nitric oxide and malondialdehyde, and (3) through a decrease in both the glutathione level and goblet cell number in mice jejuna. All these infection-induced parameters were significantly altered during treatment with ZNPs. Our results indicate, therefore, that ZNPs have protective effects against E. papillata-induced coccidiosis.Keywords: zinc nanoparticle, Eimeria, mice, jejunumDkhil MAAl-Quraishy SWahab RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 1961-1968 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dkhil MA Al-Quraishy S Wahab R Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum
description	Mohamed A Dkhil,1,2 Saleh Al-Quraishy,1 Rizwan Wahab11Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; 2Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, EgyptAbstract: Nanomedicine has recently emerged as a better option for the treatment of various diseases. Here, we investigated the in vivo anticoccidial properties of zinc oxide nanoparticles (ZNPs). ZNPs were crystalline in nature, with a smooth and spherical surface and a diameter in the range of ~10–15 nm. The X-ray diffraction pattern was utilized to identify the crystalline property of the grown ZNPs, whereas field emission scanning electron microscopy was employed to check the size and morphology of the ZNPs. The data showed that mice infected with Eimeria papillata produced 29.7×103±1,500 oocysts/g feces on day 5 postinfection. This output was significantly decreased, to 12.5×103±1,000 oocysts, in mice treated with ZNPs. Infection also induced inflammation and injury of the jejunum. This was evidenced (1) through an increase in the inflammatory histological score, (2) through increased production of nitric oxide and malondialdehyde, and (3) through a decrease in both the glutathione level and goblet cell number in mice jejuna. All these infection-induced parameters were significantly altered during treatment with ZNPs. Our results indicate, therefore, that ZNPs have protective effects against E. papillata-induced coccidiosis.Keywords: zinc nanoparticle, Eimeria, mice, jejunum
format	article
author	Dkhil MA Al-Quraishy S Wahab R
author_facet	Dkhil MA Al-Quraishy S Wahab R
author_sort	Dkhil MA
title	Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum
title_short	Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum
title_full	Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum
title_fullStr	Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum
title_full_unstemmed	Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum
title_sort	anticoccidial and antioxidant activities of zinc oxide nanoparticles on eimeria papillata-induced infection in the jejunum
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/f7a38283a0994678b74b812291976d02
work_keys_str_mv	AT dkhilma anticoccidialandantioxidantactivitiesofzincoxidenanoparticlesoneimeriapapillatainducedinfectioninthejejunum AT alquraishys anticoccidialandantioxidantactivitiesofzincoxidenanoparticlesoneimeriapapillatainducedinfectioninthejejunum AT wahabr anticoccidialandantioxidantactivitiesofzincoxidenanoparticlesoneimeriapapillatainducedinfectioninthejejunum
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Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum

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