Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia

Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia

Historical acute promyelocytic leukemia patients treated with retinoic acid and chemotherapy sometimes did relapse. Here the authors performed exome sequencing on 64 patient's samples from diagnosis/relapse/remission and show relapse associates either with cooperating oncogenes at diagnosis, or...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jacqueline Lehmann-Che, Cécile Bally, Eric Letouzé, Caroline Berthier, Hao Yuan, Florence Jollivet, Lionel Ades, Bruno Cassinat, Pierre Hirsch, Arnaud Pigneux, Marie-Joelle Mozziconacci, Scott Kogan, Pierre Fenaux, Hugues de Thé
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f7a3de80783f451da9d5fe9382b1bfea
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:f7a3de80783f451da9d5fe9382b1bfea
record_format dspace
spelling oai:doaj.org-article:f7a3de80783f451da9d5fe9382b1bfea2021-12-02T14:41:17ZDual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia10.1038/s41467-018-04384-52041-1723https://doaj.org/article/f7a3de80783f451da9d5fe9382b1bfea2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04384-5https://doaj.org/toc/2041-1723Historical acute promyelocytic leukemia patients treated with retinoic acid and chemotherapy sometimes did relapse. Here the authors performed exome sequencing on 64 patient's samples from diagnosis/relapse/remission and show relapse associates either with cooperating oncogenes at diagnosis, or with unexpected persistence of ancestral pre-leukemic clones.Jacqueline Lehmann-CheCécile BallyEric LetouzéCaroline BerthierHao YuanFlorence JollivetLionel AdesBruno CassinatPierre HirschArnaud PigneuxMarie-Joelle MozziconacciScott KoganPierre FenauxHugues de ThéNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jacqueline Lehmann-Che
Cécile Bally
Eric Letouzé
Caroline Berthier
Hao Yuan
Florence Jollivet
Lionel Ades
Bruno Cassinat
Pierre Hirsch
Arnaud Pigneux
Marie-Joelle Mozziconacci
Scott Kogan
Pierre Fenaux
Hugues de Thé
Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia
description Historical acute promyelocytic leukemia patients treated with retinoic acid and chemotherapy sometimes did relapse. Here the authors performed exome sequencing on 64 patient's samples from diagnosis/relapse/remission and show relapse associates either with cooperating oncogenes at diagnosis, or with unexpected persistence of ancestral pre-leukemic clones.
format article
author Jacqueline Lehmann-Che
Cécile Bally
Eric Letouzé
Caroline Berthier
Hao Yuan
Florence Jollivet
Lionel Ades
Bruno Cassinat
Pierre Hirsch
Arnaud Pigneux
Marie-Joelle Mozziconacci
Scott Kogan
Pierre Fenaux
Hugues de Thé
author_facet Jacqueline Lehmann-Che
Cécile Bally
Eric Letouzé
Caroline Berthier
Hao Yuan
Florence Jollivet
Lionel Ades
Bruno Cassinat
Pierre Hirsch
Arnaud Pigneux
Marie-Joelle Mozziconacci
Scott Kogan
Pierre Fenaux
Hugues de Thé
author_sort Jacqueline Lehmann-Che
title Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia
title_short Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia
title_full Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia
title_fullStr Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia
title_full_unstemmed Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia
title_sort dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/f7a3de80783f451da9d5fe9382b1bfea
work_keys_str_mv AT jacquelinelehmannche dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT cecilebally dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT ericletouze dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT carolineberthier dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT haoyuan dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT florencejollivet dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT lionelades dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT brunocassinat dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT pierrehirsch dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT arnaudpigneux dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT mariejoellemozziconacci dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT scottkogan dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT pierrefenaux dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
AT huguesdethe dualoriginofrelapsesinretinoicacidresistantacutepromyelocyticleukemia
_version_ 1718389968555999232

Ejemplares similares