THE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION

The aim of the present systematic literature review is to summarize data on the role of TLRs in maintaining homeostasis of the female genitals, in maintaining the physiological development of pregnancy, provision of anti-infective resistance in pregnant women with intrauterine infection. The review...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. V. Karaulov, S. S. Afanasiev, V. A. Aleshkin, N. L. Bondarenko, E. A. Voropaeva, M. S. Afanasiev, Yu. V. Nesvizhsky, O. Yu. Borisova, A. V. Aleshkin, Yu. N. Urban, A. B. Borisova, A. D. Voropaev
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2018
Materias:	toll-like receptors pregnancy the physiological course of pregnancy adaptive immunity physiological immunosuppression intrauterine infection homeostasis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f7a5b4111d1d489aa6c8e3746bd0ce3c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7a5b4111d1d489aa6c8e3746bd0ce3c
record_format	dspace
spelling	oai:doaj.org-article:f7a5b4111d1d489aa6c8e3746bd0ce3c2021-11-22T07:09:49ZTHE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION2220-76192313-739810.15789/2220-7619-2018-3-251-262https://doaj.org/article/f7a5b4111d1d489aa6c8e3746bd0ce3c2018-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/773https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The aim of the present systematic literature review is to summarize data on the role of TLRs in maintaining homeostasis of the female genitals, in maintaining the physiological development of pregnancy, provision of anti-infective resistance in pregnant women with intrauterine infection. The review substantiates the importance of TLRs of female genitals as a necessary and determining factor in the reaction to various changes in the environment, and also responsible for changes in metabolic, structural, or energy, in the maintenance of anti-infective resistance and homeostasis. As universal regulators of vital activity of organism TLRs in conjunction with other receptors of innate immunity provide maintaining the general reactivity and anti-infective resistance at the physiological level. In physiologically developing pregnancy in a background of immunosuppression in response to pregnancy TLRs during contact with infectious and non-infectious pathogens stimulate the production of nonspecific adaptive immunity factors (defensins, cathelicidins, histatines, etc.), which together with the non-specific innate factors lysozyme, complement, properdin, etc. support antiinfective resistance of the female genitals at a high level at the beginning of the infectious process. Possible violations of the development of pregnancy may be accompanied by changes in the response of TLRs to infectious and non-infectious factors until hyper-reaction, excessive inflammation or apoptosis, which requires adequate management of pregnancy. Was established the significance of the influence of pathogens of infectious and noninfectious origin in intrauterine infection indirectly through TLRs in the homeostasis of the organism, on the formation of breaches in anti-infective resistance at the organism and community level the identification of new pathophysiological and immunological pathogenetic mechanisms of development of pathological processes. IUI is a penetration of microorganisms into the tissues of fetus and it’s infection. The inhibition of the functional activity of TLRs is accompanied by the direct effect of the pathogen on the tissues, and during hyper-reaction of TLRs to pathogens revealed a pronounced inflammatory response in the fetus. The level of expression of TLRs correlates directly with the severity of the process that can be considered as early markers of infection. Depending on the nature of the pathogen an increased expression of one or the other TLRs is observed. Explained the lack of symptoms, the possibility of atypical manifestations, the asymptomatic course of infection.A. V. KaraulovS. S. AfanasievV. A. AleshkinN. L. BondarenkoE. A. VoropaevaM. S. AfanasievYu. V. NesvizhskyO. Yu. BorisovaA. V. AleshkinYu. N. UrbanA. B. BorisovaA. D. VoropaevSankt-Peterburg : NIIÈM imeni Pasteraarticletoll-like receptorspregnancythe physiological course of pregnancyadaptive immunityphysiological immunosuppressionintrauterine infectionhomeostasisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 8, Iss 3, Pp 251-262 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	toll-like receptors pregnancy the physiological course of pregnancy adaptive immunity physiological immunosuppression intrauterine infection homeostasis Infectious and parasitic diseases RC109-216
spellingShingle	toll-like receptors pregnancy the physiological course of pregnancy adaptive immunity physiological immunosuppression intrauterine infection homeostasis Infectious and parasitic diseases RC109-216 A. V. Karaulov S. S. Afanasiev V. A. Aleshkin N. L. Bondarenko E. A. Voropaeva M. S. Afanasiev Yu. V. Nesvizhsky O. Yu. Borisova A. V. Aleshkin Yu. N. Urban A. B. Borisova A. D. Voropaev THE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION
description	The aim of the present systematic literature review is to summarize data on the role of TLRs in maintaining homeostasis of the female genitals, in maintaining the physiological development of pregnancy, provision of anti-infective resistance in pregnant women with intrauterine infection. The review substantiates the importance of TLRs of female genitals as a necessary and determining factor in the reaction to various changes in the environment, and also responsible for changes in metabolic, structural, or energy, in the maintenance of anti-infective resistance and homeostasis. As universal regulators of vital activity of organism TLRs in conjunction with other receptors of innate immunity provide maintaining the general reactivity and anti-infective resistance at the physiological level. In physiologically developing pregnancy in a background of immunosuppression in response to pregnancy TLRs during contact with infectious and non-infectious pathogens stimulate the production of nonspecific adaptive immunity factors (defensins, cathelicidins, histatines, etc.), which together with the non-specific innate factors lysozyme, complement, properdin, etc. support antiinfective resistance of the female genitals at a high level at the beginning of the infectious process. Possible violations of the development of pregnancy may be accompanied by changes in the response of TLRs to infectious and non-infectious factors until hyper-reaction, excessive inflammation or apoptosis, which requires adequate management of pregnancy. Was established the significance of the influence of pathogens of infectious and noninfectious origin in intrauterine infection indirectly through TLRs in the homeostasis of the organism, on the formation of breaches in anti-infective resistance at the organism and community level the identification of new pathophysiological and immunological pathogenetic mechanisms of development of pathological processes. IUI is a penetration of microorganisms into the tissues of fetus and it’s infection. The inhibition of the functional activity of TLRs is accompanied by the direct effect of the pathogen on the tissues, and during hyper-reaction of TLRs to pathogens revealed a pronounced inflammatory response in the fetus. The level of expression of TLRs correlates directly with the severity of the process that can be considered as early markers of infection. Depending on the nature of the pathogen an increased expression of one or the other TLRs is observed. Explained the lack of symptoms, the possibility of atypical manifestations, the asymptomatic course of infection.
format	article
author	A. V. Karaulov S. S. Afanasiev V. A. Aleshkin N. L. Bondarenko E. A. Voropaeva M. S. Afanasiev Yu. V. Nesvizhsky O. Yu. Borisova A. V. Aleshkin Yu. N. Urban A. B. Borisova A. D. Voropaev
author_facet	A. V. Karaulov S. S. Afanasiev V. A. Aleshkin N. L. Bondarenko E. A. Voropaeva M. S. Afanasiev Yu. V. Nesvizhsky O. Yu. Borisova A. V. Aleshkin Yu. N. Urban A. B. Borisova A. D. Voropaev
author_sort	A. V. Karaulov
title	THE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION
title_short	THE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION
title_full	THE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION
title_fullStr	THE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION
title_full_unstemmed	THE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION
title_sort	role of innate immunity receptors (tlrs) in maintaining the homeostasis of the female genital tract in developing pregnancy and intrauterine infection
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2018
url	https://doaj.org/article/f7a5b4111d1d489aa6c8e3746bd0ce3c
work_keys_str_mv	AT avkaraulov theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT ssafanasiev theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT vaaleshkin theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT nlbondarenko theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT eavoropaeva theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT msafanasiev theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT yuvnesvizhsky theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT oyuborisova theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT avaleshkin theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT yunurban theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT abborisova theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT advoropaev theroleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT avkaraulov roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT ssafanasiev roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT vaaleshkin roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT nlbondarenko roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT eavoropaeva roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT msafanasiev roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT yuvnesvizhsky roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT oyuborisova roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT avaleshkin roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT yunurban roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT abborisova roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection AT advoropaev roleofinnateimmunityreceptorstlrsinmaintainingthehomeostasisofthefemalegenitaltractindevelopingpregnancyandintrauterineinfection
_version_	1718418017127235584

THE ROLE OF INNATE IMMUNITY RECEPTORS (TLRs) IN MAINTAINING THE HOMEOSTASIS OF THE FEMALE GENITAL TRACT IN DEVELOPING PREGNANCY AND INTRAUTERINE INFECTION

Ejemplares similares