Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes

Both insulin and IGF-1 signaling have been implicated in arterial intimal hyperplasia. Here the authors dissect the relative contributions of insulin and IGF-1 receptors, showing that homodimers of insulin receptors, but not IGF-1 receptor, induce proliferation of vascular smooth muscle cells.

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Autores principales:	Qian Li, Jialin Fu, Yu Xia, Weier Qi, Atsushi Ishikado, Kyoungmin Park, Hisashi Yokomizo, Qian Huang, Weikang Cai, Christian Rask-Madsen, C. Ronald Kahn, George L. King
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7a6e495b3f846cbb7d42345bf6c4a5a
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spelling	oai:doaj.org-article:f7a6e495b3f846cbb7d42345bf6c4a5a2021-12-02T17:02:18ZHomozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes10.1038/s41467-019-12368-22041-1723https://doaj.org/article/f7a6e495b3f846cbb7d42345bf6c4a5a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12368-2https://doaj.org/toc/2041-1723Both insulin and IGF-1 signaling have been implicated in arterial intimal hyperplasia. Here the authors dissect the relative contributions of insulin and IGF-1 receptors, showing that homodimers of insulin receptors, but not IGF-1 receptor, induce proliferation of vascular smooth muscle cells.Qian LiJialin FuYu XiaWeier QiAtsushi IshikadoKyoungmin ParkHisashi YokomizoQian HuangWeikang CaiChristian Rask-MadsenC. Ronald KahnGeorge L. KingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Li Jialin Fu Yu Xia Weier Qi Atsushi Ishikado Kyoungmin Park Hisashi Yokomizo Qian Huang Weikang Cai Christian Rask-Madsen C. Ronald Kahn George L. King Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
description	Both insulin and IGF-1 signaling have been implicated in arterial intimal hyperplasia. Here the authors dissect the relative contributions of insulin and IGF-1 receptors, showing that homodimers of insulin receptors, but not IGF-1 receptor, induce proliferation of vascular smooth muscle cells.
format	article
author	Qian Li Jialin Fu Yu Xia Weier Qi Atsushi Ishikado Kyoungmin Park Hisashi Yokomizo Qian Huang Weikang Cai Christian Rask-Madsen C. Ronald Kahn George L. King
author_facet	Qian Li Jialin Fu Yu Xia Weier Qi Atsushi Ishikado Kyoungmin Park Hisashi Yokomizo Qian Huang Weikang Cai Christian Rask-Madsen C. Ronald Kahn George L. King
author_sort	Qian Li
title	Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
title_short	Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
title_full	Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
title_fullStr	Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
title_full_unstemmed	Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes
title_sort	homozygous receptors for insulin and not igf-1 accelerate intimal hyperplasia in insulin resistance and diabetes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f7a6e495b3f846cbb7d42345bf6c4a5a
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Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes

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