The causal interaction in human basal ganglia

Abstract The experimental study of the human brain has important restrictions, particularly in the case of basal ganglia, subcortical centers whose activity can be recorded with fMRI methods but cannot be directly modified. Similar restrictions occur in other complex systems such as those studied by...

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Autores principales:	Clara Rodriguez-Sabate, Albano Gonzalez, Juan Carlos Perez-Darias, Ingrid Morales, Manuel Rodriguez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7a99454ab8d482e8cbf9acf4eee55c3
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spelling	oai:doaj.org-article:f7a99454ab8d482e8cbf9acf4eee55c32021-12-02T16:07:04ZThe causal interaction in human basal ganglia10.1038/s41598-021-92490-82045-2322https://doaj.org/article/f7a99454ab8d482e8cbf9acf4eee55c32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92490-8https://doaj.org/toc/2045-2322Abstract The experimental study of the human brain has important restrictions, particularly in the case of basal ganglia, subcortical centers whose activity can be recorded with fMRI methods but cannot be directly modified. Similar restrictions occur in other complex systems such as those studied by Earth system science. The present work studied the cause/effect relationships between human basal ganglia with recently introduced methods to study climate dynamics. Data showed an exhaustive (identifying basal ganglia interactions regardless of their linear, non-linear or complex nature) and selective (avoiding spurious relationships) view of basal ganglia activity, showing a fast functional reconfiguration of their main centers during the execution of voluntary motor tasks. The methodology used here offers a novel view of the human basal ganglia which expands the perspective provided by the classical basal ganglia model and may help to understand BG activity under normal and pathological conditions.Clara Rodriguez-SabateAlbano GonzalezJuan Carlos Perez-DariasIngrid MoralesManuel RodriguezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clara Rodriguez-Sabate Albano Gonzalez Juan Carlos Perez-Darias Ingrid Morales Manuel Rodriguez The causal interaction in human basal ganglia
description	Abstract The experimental study of the human brain has important restrictions, particularly in the case of basal ganglia, subcortical centers whose activity can be recorded with fMRI methods but cannot be directly modified. Similar restrictions occur in other complex systems such as those studied by Earth system science. The present work studied the cause/effect relationships between human basal ganglia with recently introduced methods to study climate dynamics. Data showed an exhaustive (identifying basal ganglia interactions regardless of their linear, non-linear or complex nature) and selective (avoiding spurious relationships) view of basal ganglia activity, showing a fast functional reconfiguration of their main centers during the execution of voluntary motor tasks. The methodology used here offers a novel view of the human basal ganglia which expands the perspective provided by the classical basal ganglia model and may help to understand BG activity under normal and pathological conditions.
format	article
author	Clara Rodriguez-Sabate Albano Gonzalez Juan Carlos Perez-Darias Ingrid Morales Manuel Rodriguez
author_facet	Clara Rodriguez-Sabate Albano Gonzalez Juan Carlos Perez-Darias Ingrid Morales Manuel Rodriguez
author_sort	Clara Rodriguez-Sabate
title	The causal interaction in human basal ganglia
title_short	The causal interaction in human basal ganglia
title_full	The causal interaction in human basal ganglia
title_fullStr	The causal interaction in human basal ganglia
title_full_unstemmed	The causal interaction in human basal ganglia
title_sort	causal interaction in human basal ganglia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7a99454ab8d482e8cbf9acf4eee55c3
work_keys_str_mv	AT clararodriguezsabate thecausalinteractioninhumanbasalganglia AT albanogonzalez thecausalinteractioninhumanbasalganglia AT juancarlosperezdarias thecausalinteractioninhumanbasalganglia AT ingridmorales thecausalinteractioninhumanbasalganglia AT manuelrodriguez thecausalinteractioninhumanbasalganglia AT clararodriguezsabate causalinteractioninhumanbasalganglia AT albanogonzalez causalinteractioninhumanbasalganglia AT juancarlosperezdarias causalinteractioninhumanbasalganglia AT ingridmorales causalinteractioninhumanbasalganglia AT manuelrodriguez causalinteractioninhumanbasalganglia
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The causal interaction in human basal ganglia

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