Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.

<h4>Objective</h4>Low grade systemic inflammation (LGSI) as well as androgen deficiency has in older men been associated with several pathologies, including cardiovascular disease (CVD). We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in...

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Autores principales:	Johannes Bobjer, Marianna Katrinaki, Christos Tsatsanis, Yvonne Lundberg Giwercman, Aleksander Giwercman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7a9e31d3c8b4764a55700b51f8ee4e1
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spelling	oai:doaj.org-article:f7a9e31d3c8b4764a55700b51f8ee4e12021-11-18T07:48:53ZNegative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.1932-620310.1371/journal.pone.0061466https://doaj.org/article/f7a9e31d3c8b4764a55700b51f8ee4e12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23637840/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Low grade systemic inflammation (LGSI) as well as androgen deficiency has in older men been associated with several pathologies, including cardiovascular disease (CVD). We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in young age, before any concurrent manifestations of CVD or other systemic diseases.<h4>Design</h4>Nested cross-sectional study.<h4>Methods</h4>Forty subfertile biochemically hypogonadal (n = 20) or eugonadal (n = 20) men (mean age 37 years, SD = 4.3) and 20 age-matched controls were randomly selected from an ongoing study on male subfertility. Subjects comprised male partners in infertile couples in whom also subnormal sperm concentration was present. Blood sampling, interviews, and anthropometric measures were undertaken. Serum levels of testosterone, LH, estradiol, SHBG, and 21 LGSI-markers were assessed.<h4>Results</h4>Among 21 inflammatory markers, macrophage inflammatory protein 1-alpha (MIP1a) (ß = -0.025; p = 0.028), 1-beta (MIP1B) (ß = -0.015; p = 0.049) and tumor necrosis factor alpha (TNFa) (ß = -0.015; p = 0.040) showed negative association to total testosterone (TT) levels. MIP1a (ß = -1.95; p = 0.001) and TNFa (ß = -0.95; p = 0.014) showed negative association to calculated free testosterone (cFT) levels. Compared to men with normal TT and cFT levels, TNFa levels were higher in men with subnormal levels of TT (mean ratio 1.61; p = 0.006) and cFT (mean ratio 1.58; p = 0.007). Also, MIP1a levels were higher in men with subnormal levels of TT (mean ratio 1.84; p = 0.030).<h4>Conclusions</h4>Subnormal testosterone may already in young age associate to LGSI, which might be a part of the mechanism underlying adverse health outcomes of male hypogonadism.Johannes BobjerMarianna KatrinakiChristos TsatsanisYvonne Lundberg GiwercmanAleksander GiwercmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61466 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Johannes Bobjer Marianna Katrinaki Christos Tsatsanis Yvonne Lundberg Giwercman Aleksander Giwercman Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
description	<h4>Objective</h4>Low grade systemic inflammation (LGSI) as well as androgen deficiency has in older men been associated with several pathologies, including cardiovascular disease (CVD). We wanted to investigate whether low testosterone levels are linked to biomarkers of LGSI already in young age, before any concurrent manifestations of CVD or other systemic diseases.<h4>Design</h4>Nested cross-sectional study.<h4>Methods</h4>Forty subfertile biochemically hypogonadal (n = 20) or eugonadal (n = 20) men (mean age 37 years, SD = 4.3) and 20 age-matched controls were randomly selected from an ongoing study on male subfertility. Subjects comprised male partners in infertile couples in whom also subnormal sperm concentration was present. Blood sampling, interviews, and anthropometric measures were undertaken. Serum levels of testosterone, LH, estradiol, SHBG, and 21 LGSI-markers were assessed.<h4>Results</h4>Among 21 inflammatory markers, macrophage inflammatory protein 1-alpha (MIP1a) (ß = -0.025; p = 0.028), 1-beta (MIP1B) (ß = -0.015; p = 0.049) and tumor necrosis factor alpha (TNFa) (ß = -0.015; p = 0.040) showed negative association to total testosterone (TT) levels. MIP1a (ß = -1.95; p = 0.001) and TNFa (ß = -0.95; p = 0.014) showed negative association to calculated free testosterone (cFT) levels. Compared to men with normal TT and cFT levels, TNFa levels were higher in men with subnormal levels of TT (mean ratio 1.61; p = 0.006) and cFT (mean ratio 1.58; p = 0.007). Also, MIP1a levels were higher in men with subnormal levels of TT (mean ratio 1.84; p = 0.030).<h4>Conclusions</h4>Subnormal testosterone may already in young age associate to LGSI, which might be a part of the mechanism underlying adverse health outcomes of male hypogonadism.
format	article
author	Johannes Bobjer Marianna Katrinaki Christos Tsatsanis Yvonne Lundberg Giwercman Aleksander Giwercman
author_facet	Johannes Bobjer Marianna Katrinaki Christos Tsatsanis Yvonne Lundberg Giwercman Aleksander Giwercman
author_sort	Johannes Bobjer
title	Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
title_short	Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
title_full	Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
title_fullStr	Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
title_full_unstemmed	Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
title_sort	negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f7a9e31d3c8b4764a55700b51f8ee4e1
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Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study.

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