Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis

Abstract To investigate the effects of age at diagnosis on metastatic breast cancer and patients’ prognosis, we collected patient data from the Surveillance, Epidemiology, and End Results (SEER) database. We finally identified 4932 eligible metastatic breast cancer patients diagnosed between 2010–20...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Meng-Ting Chen, He-Fen Sun, Yang Zhao, Wen-Yan Fu, Li-Peng Yang, Shui-Ping Gao, Liang-Dong Li, Hong-lin Jiang, Wei Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7aafd19990643d5b842a58aa39bfd97
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7aafd19990643d5b842a58aa39bfd97
record_format	dspace
spelling	oai:doaj.org-article:f7aafd19990643d5b842a58aa39bfd972021-12-02T15:05:45ZComparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis10.1038/s41598-017-10166-82045-2322https://doaj.org/article/f7aafd19990643d5b842a58aa39bfd972017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-10166-8https://doaj.org/toc/2045-2322Abstract To investigate the effects of age at diagnosis on metastatic breast cancer and patients’ prognosis, we collected patient data from the Surveillance, Epidemiology, and End Results (SEER) database. We finally identified 4932 eligible metastatic breast cancer patients diagnosed between 2010–2013, including 850 younger patients (<50 years), 2,540 middle-aged patients (50–69 years) and 1,542 elder patients (>69 years). The results revealed that in stage IV patients, elder patients were more likely to have lung metastasis (P < 0.001) and less likely to have only distant lymphatic spread (P = 0.004). Higher proportion of younger (34.9%) and middle-aged (36.2%) patients had multiple metastatic sites than elder patients (28.3%) (P < 0.001). In survival analysis, younger patients presented the best prognosis, while elder patients had the worst both in overall survival (χ2 = 121.9, P < 0.001) and breast cancer-specific survival (χ2 = 69.8, P < 0.001). Age at diagnosis was an independent prognostic factor for metastatic breast cancer patients. Moreover, patients with bone metastasis only had superior survival compared to other metastatic patients (P < 0.001). Brain metastasis only group and multiple sites metastasis group had the poorest prognosis (P < 0.05). We hope the results will provide insights into a better understanding of distant metastatic breast cancer.Meng-Ting ChenHe-Fen SunYang ZhaoWen-Yan FuLi-Peng YangShui-Ping GaoLiang-Dong LiHong-lin JiangWei JinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meng-Ting Chen He-Fen Sun Yang Zhao Wen-Yan Fu Li-Peng Yang Shui-Ping Gao Liang-Dong Li Hong-lin Jiang Wei Jin Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis
description	Abstract To investigate the effects of age at diagnosis on metastatic breast cancer and patients’ prognosis, we collected patient data from the Surveillance, Epidemiology, and End Results (SEER) database. We finally identified 4932 eligible metastatic breast cancer patients diagnosed between 2010–2013, including 850 younger patients (<50 years), 2,540 middle-aged patients (50–69 years) and 1,542 elder patients (>69 years). The results revealed that in stage IV patients, elder patients were more likely to have lung metastasis (P < 0.001) and less likely to have only distant lymphatic spread (P = 0.004). Higher proportion of younger (34.9%) and middle-aged (36.2%) patients had multiple metastatic sites than elder patients (28.3%) (P < 0.001). In survival analysis, younger patients presented the best prognosis, while elder patients had the worst both in overall survival (χ2 = 121.9, P < 0.001) and breast cancer-specific survival (χ2 = 69.8, P < 0.001). Age at diagnosis was an independent prognostic factor for metastatic breast cancer patients. Moreover, patients with bone metastasis only had superior survival compared to other metastatic patients (P < 0.001). Brain metastasis only group and multiple sites metastasis group had the poorest prognosis (P < 0.05). We hope the results will provide insights into a better understanding of distant metastatic breast cancer.
format	article
author	Meng-Ting Chen He-Fen Sun Yang Zhao Wen-Yan Fu Li-Peng Yang Shui-Ping Gao Liang-Dong Li Hong-lin Jiang Wei Jin
author_facet	Meng-Ting Chen He-Fen Sun Yang Zhao Wen-Yan Fu Li-Peng Yang Shui-Ping Gao Liang-Dong Li Hong-lin Jiang Wei Jin
author_sort	Meng-Ting Chen
title	Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis
title_short	Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis
title_full	Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis
title_fullStr	Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis
title_full_unstemmed	Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis
title_sort	comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a seer population-based analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f7aafd19990643d5b842a58aa39bfd97
work_keys_str_mv	AT mengtingchen comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis AT hefensun comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis AT yangzhao comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis AT wenyanfu comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis AT lipengyang comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis AT shuipinggao comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis AT liangdongli comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis AT honglinjiang comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis AT weijin comparisonofpatternsandprognosisamongdistantmetastaticbreastcancerpatientsbyagegroupsaseerpopulationbasedanalysis
_version_	1718388744882487296

Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis

Ejemplares similares