Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka
Background: As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV-2 outbreak.Methods: SARS-CoV-2 seropo...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:f7ab4bcfc1b940dca4f4af91b5a2bd0e2021-11-12T05:01:01ZSeroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka2296-256510.3389/fpubh.2021.724398https://doaj.org/article/f7ab4bcfc1b940dca4f4af91b5a2bd0e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.724398/fullhttps://doaj.org/toc/2296-2565Background: As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV-2 outbreak.Methods: SARS-CoV-2 seropositivity was determined in 2,547 individuals between the ages of 10–86 years, by the Wantai total antibody ELISA. We also compared seroprevalence using the haemagglutination test (HAT) to evaluate its usefulness in carrying out serosurveys.Results: The overall seropositivity rate was 24.46%, while seropositivity by HAT was 18.90%. Although The SARS-CoV-2 infection detection rates by PCR were highest in the population between the ages of 20–60 years of age, there was no statistically significant difference in the seropositivity rates in different age groups. For instance, although the seropositivity rate was highest in the 10–20 age group (34.03%), the PCR positivity rate was 9.80%. Differences in the PCR positivity rates and seropositivity rates were also seen in 60–70-year-olds (8.90 vs. 30.4%) and in individuals >70 years (4.10 vs. 1.20%). The seropositivity rate of the females was 29.70% (290/976), which was significantly higher (p < 0.002) than in males 21.2% (333/1,571).Conclusions: A high seroprevalence rate (24.5%) was seen in all age groups in the CMC suggesting that a high level of transmission was seen during this time. The higher PCR positivity rates between the ages of 20–60 are likely to be due to increased testing carried out in the working population. Therefore, the PCR positivity rates, appear to underestimate the true extent of the outbreak and the age groups which were infected.Chandima JeewandaraDinuka GurugeInoka Sepali AbyrathnaSaubhagya DanasekaraBanuri GunasekeraPradeep Darshana PushpakumaraDeshan MadhusankaDeshni JayathilakaThushali RanasingheGayasha SomathilakeShyrar TanussiyaTibutius Tanesh JayadasHeshan KuruppuNimasha ThashmiMichael HarvieRuwan WijayamuniLisa SchimanskiLisa SchimanskiT. K. TanT. K. TanPramila RijalPramila RijalJulie XiaoJulie XiaoGraham S. OggAlain TownsendAlain TownsendGathsaurie Neelika MalavigeGathsaurie Neelika MalavigeFrontiers Media S.A.articleserosurveillanceSARS-CoV-2Sri LankaColomboantibodiesseropositivityPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021) |
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serosurveillance SARS-CoV-2 Sri Lanka Colombo antibodies seropositivity Public aspects of medicine RA1-1270 |
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serosurveillance SARS-CoV-2 Sri Lanka Colombo antibodies seropositivity Public aspects of medicine RA1-1270 Chandima Jeewandara Dinuka Guruge Inoka Sepali Abyrathna Saubhagya Danasekara Banuri Gunasekera Pradeep Darshana Pushpakumara Deshan Madhusanka Deshni Jayathilaka Thushali Ranasinghe Gayasha Somathilake Shyrar Tanussiya Tibutius Tanesh Jayadas Heshan Kuruppu Nimasha Thashmi Michael Harvie Ruwan Wijayamuni Lisa Schimanski Lisa Schimanski T. K. Tan T. K. Tan Pramila Rijal Pramila Rijal Julie Xiao Julie Xiao Graham S. Ogg Alain Townsend Alain Townsend Gathsaurie Neelika Malavige Gathsaurie Neelika Malavige Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka |
| description |
Background: As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV-2 outbreak.Methods: SARS-CoV-2 seropositivity was determined in 2,547 individuals between the ages of 10–86 years, by the Wantai total antibody ELISA. We also compared seroprevalence using the haemagglutination test (HAT) to evaluate its usefulness in carrying out serosurveys.Results: The overall seropositivity rate was 24.46%, while seropositivity by HAT was 18.90%. Although The SARS-CoV-2 infection detection rates by PCR were highest in the population between the ages of 20–60 years of age, there was no statistically significant difference in the seropositivity rates in different age groups. For instance, although the seropositivity rate was highest in the 10–20 age group (34.03%), the PCR positivity rate was 9.80%. Differences in the PCR positivity rates and seropositivity rates were also seen in 60–70-year-olds (8.90 vs. 30.4%) and in individuals >70 years (4.10 vs. 1.20%). The seropositivity rate of the females was 29.70% (290/976), which was significantly higher (p < 0.002) than in males 21.2% (333/1,571).Conclusions: A high seroprevalence rate (24.5%) was seen in all age groups in the CMC suggesting that a high level of transmission was seen during this time. The higher PCR positivity rates between the ages of 20–60 are likely to be due to increased testing carried out in the working population. Therefore, the PCR positivity rates, appear to underestimate the true extent of the outbreak and the age groups which were infected. |
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article |
| author |
Chandima Jeewandara Dinuka Guruge Inoka Sepali Abyrathna Saubhagya Danasekara Banuri Gunasekera Pradeep Darshana Pushpakumara Deshan Madhusanka Deshni Jayathilaka Thushali Ranasinghe Gayasha Somathilake Shyrar Tanussiya Tibutius Tanesh Jayadas Heshan Kuruppu Nimasha Thashmi Michael Harvie Ruwan Wijayamuni Lisa Schimanski Lisa Schimanski T. K. Tan T. K. Tan Pramila Rijal Pramila Rijal Julie Xiao Julie Xiao Graham S. Ogg Alain Townsend Alain Townsend Gathsaurie Neelika Malavige Gathsaurie Neelika Malavige |
| author_facet |
Chandima Jeewandara Dinuka Guruge Inoka Sepali Abyrathna Saubhagya Danasekara Banuri Gunasekera Pradeep Darshana Pushpakumara Deshan Madhusanka Deshni Jayathilaka Thushali Ranasinghe Gayasha Somathilake Shyrar Tanussiya Tibutius Tanesh Jayadas Heshan Kuruppu Nimasha Thashmi Michael Harvie Ruwan Wijayamuni Lisa Schimanski Lisa Schimanski T. K. Tan T. K. Tan Pramila Rijal Pramila Rijal Julie Xiao Julie Xiao Graham S. Ogg Alain Townsend Alain Townsend Gathsaurie Neelika Malavige Gathsaurie Neelika Malavige |
| author_sort |
Chandima Jeewandara |
| title |
Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka |
| title_short |
Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka |
| title_full |
Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka |
| title_fullStr |
Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka |
| title_full_unstemmed |
Seroprevalence of SARS-CoV-2 Infection in the Colombo Municipality Region, Sri Lanka |
| title_sort |
seroprevalence of sars-cov-2 infection in the colombo municipality region, sri lanka |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/f7ab4bcfc1b940dca4f4af91b5a2bd0e |
| work_keys_str_mv |
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