Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
Materials based on calcium carbonate (CaCO<sub>3</sub>) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO<sub>3</sub> and dependence of its stability on pH make these materials promising transporters of therapeuti...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/f7ac4f04face422bb0d8ac2be0d490f8 |
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| Sumario: | Materials based on calcium carbonate (CaCO<sub>3</sub>) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO<sub>3</sub> and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO<sub>3</sub> (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: <i>DOX</i>orubicin (<i>DOX</i>). We also showed a prolonged pH-dependent release of <i>DOX</i> from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO<sub>3</sub>-and-<i>DOX</i>–based composite (CaNP<sub>7</sub>-<i>DOX</i>) in in vitro models. |
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