Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug

Materials based on calcium carbonate (CaCO<sub>3</sub>) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO<sub>3</sub> and dependence of its stability on pH make these materials promising transporters of therapeuti...

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Autores principales:	Victoriya Popova, Yuliya Poletaeva, Inna Pyshnaya, Dmitrii Pyshnyi, Elena Dmitrienko
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	calcium carbonate nanoparticle <i>DOX</i>orubicin prolonged release Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f7ac4f04face422bb0d8ac2be0d490f8
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spelling	oai:doaj.org-article:f7ac4f04face422bb0d8ac2be0d490f82021-11-25T18:29:51ZDesigning pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug10.3390/nano111127942079-4991https://doaj.org/article/f7ac4f04face422bb0d8ac2be0d490f82021-10-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2794https://doaj.org/toc/2079-4991Materials based on calcium carbonate (CaCO<sub>3</sub>) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO<sub>3</sub> and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO<sub>3</sub> (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: <i>DOX</i>orubicin (<i>DOX</i>). We also showed a prolonged pH-dependent release of <i>DOX</i> from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO<sub>3</sub>-and-<i>DOX</i>–based composite (CaNP<sub>7</sub>-<i>DOX</i>) in in vitro models.Victoriya PopovaYuliya PoletaevaInna PyshnayaDmitrii PyshnyiElena DmitrienkoMDPI AGarticlecalcium carbonate nanoparticle<i>DOX</i>orubicinprolonged releaseChemistryQD1-999ENNanomaterials, Vol 11, Iss 2794, p 2794 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcium carbonate nanoparticle <i>DOX</i>orubicin prolonged release Chemistry QD1-999
spellingShingle	calcium carbonate nanoparticle <i>DOX</i>orubicin prolonged release Chemistry QD1-999 Victoriya Popova Yuliya Poletaeva Inna Pyshnaya Dmitrii Pyshnyi Elena Dmitrienko Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
description	Materials based on calcium carbonate (CaCO<sub>3</sub>) are widely used in biomedical research (e.g., as carriers of bioactive substances). The biocompatibility of CaCO<sub>3</sub> and dependence of its stability on pH make these materials promising transporters of therapeutic agents to sites with low pH such as a tumor tissue. In this work, we developed an approach to the preparation of nanoscale particles based on CaCO<sub>3</sub> (CaNPs) up to 200 nm in size by coprecipitation and analyzed the interaction of the nanoparticles with an anticancer drug: <i>DOX</i>orubicin (<i>DOX</i>). We also showed a prolonged pH-dependent release of <i>DOX</i> from a CaNP nanocarrier and effective inhibition of cancer cell growth by a CaCO<sub>3</sub>-and-<i>DOX</i>–based composite (CaNP<sub>7</sub>-<i>DOX</i>) in in vitro models.
format	article
author	Victoriya Popova Yuliya Poletaeva Inna Pyshnaya Dmitrii Pyshnyi Elena Dmitrienko
author_facet	Victoriya Popova Yuliya Poletaeva Inna Pyshnaya Dmitrii Pyshnyi Elena Dmitrienko
author_sort	Victoriya Popova
title	Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
title_short	Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
title_full	Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
title_fullStr	Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
title_full_unstemmed	Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug
title_sort	designing ph-dependent systems based on nanoscale calcium carbonate for the delivery of an antitumor drug
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f7ac4f04face422bb0d8ac2be0d490f8
work_keys_str_mv	AT victoriyapopova designingphdependentsystemsbasedonnanoscalecalciumcarbonateforthedeliveryofanantitumordrug AT yuliyapoletaeva designingphdependentsystemsbasedonnanoscalecalciumcarbonateforthedeliveryofanantitumordrug AT innapyshnaya designingphdependentsystemsbasedonnanoscalecalciumcarbonateforthedeliveryofanantitumordrug AT dmitriipyshnyi designingphdependentsystemsbasedonnanoscalecalciumcarbonateforthedeliveryofanantitumordrug AT elenadmitrienko designingphdependentsystemsbasedonnanoscalecalciumcarbonateforthedeliveryofanantitumordrug
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Designing pH-Dependent Systems Based on Nanoscale Calcium Carbonate for the Delivery of an Antitumor Drug

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