KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

Epigenetic factors can regulate functional properties of human colorectal cancer stem cells. Here, the authors show that histone demethylases of the KDM3 family activate Wnt signalling in colorectal cancer stem cells by erasing H3K9me2 marks on Wnt target genes and recruiting MLL1 to promote H3K4 me...

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Autores principales:	Jiong Li, Bo Yu, Peng Deng, Yingduan Cheng, Yongxin Yu, Kareena Kevork, Sivakumar Ramadoss, Xiangming Ding, Xinmin Li, Cun-Yu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7b1ac2651da459c8bb958652feabd9c
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spelling	oai:doaj.org-article:f7b1ac2651da459c8bb958652feabd9c2021-12-02T14:40:22ZKDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling10.1038/ncomms151462041-1723https://doaj.org/article/f7b1ac2651da459c8bb958652feabd9c2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15146https://doaj.org/toc/2041-1723Epigenetic factors can regulate functional properties of human colorectal cancer stem cells. Here, the authors show that histone demethylases of the KDM3 family activate Wnt signalling in colorectal cancer stem cells by erasing H3K9me2 marks on Wnt target genes and recruiting MLL1 to promote H3K4 methylation.Jiong LiBo YuPeng DengYingduan ChengYongxin YuKareena KevorkSivakumar RamadossXiangming DingXinmin LiCun-Yu WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiong Li Bo Yu Peng Deng Yingduan Cheng Yongxin Yu Kareena Kevork Sivakumar Ramadoss Xiangming Ding Xinmin Li Cun-Yu Wang KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling
description	Epigenetic factors can regulate functional properties of human colorectal cancer stem cells. Here, the authors show that histone demethylases of the KDM3 family activate Wnt signalling in colorectal cancer stem cells by erasing H3K9me2 marks on Wnt target genes and recruiting MLL1 to promote H3K4 methylation.
format	article
author	Jiong Li Bo Yu Peng Deng Yingduan Cheng Yongxin Yu Kareena Kevork Sivakumar Ramadoss Xiangming Ding Xinmin Li Cun-Yu Wang
author_facet	Jiong Li Bo Yu Peng Deng Yingduan Cheng Yongxin Yu Kareena Kevork Sivakumar Ramadoss Xiangming Ding Xinmin Li Cun-Yu Wang
author_sort	Jiong Li
title	KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling
title_short	KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling
title_full	KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling
title_fullStr	KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling
title_full_unstemmed	KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling
title_sort	kdm3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through wnt/β-catenin signalling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f7b1ac2651da459c8bb958652feabd9c
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KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling

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