Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides

Capture of low-abundance multiply phosphorylated peptides (MPPs) is difficult due to limitation of enrichment materials and their interactions with phosphates. Here the authors show, a smart polymer driven by specific but tunable hydrogen bonding interactions can differentially complex with MPPs, si...

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Autores principales:	Guangyan Qing, Qi Lu, Xiuling Li, Jing Liu, Mingliang Ye, Xinmiao Liang, Taolei Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7b27a5d690045c6970c757ffb33811a
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spelling	oai:doaj.org-article:f7b27a5d690045c6970c757ffb33811a2021-12-02T15:37:00ZHydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides10.1038/s41467-017-00464-02041-1723https://doaj.org/article/f7b27a5d690045c6970c757ffb33811a2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00464-0https://doaj.org/toc/2041-1723Capture of low-abundance multiply phosphorylated peptides (MPPs) is difficult due to limitation of enrichment materials and their interactions with phosphates. Here the authors show, a smart polymer driven by specific but tunable hydrogen bonding interactions can differentially complex with MPPs, singly phosphorylated and non-modified peptides.Guangyan QingQi LuXiuling LiJing LiuMingliang YeXinmiao LiangTaolei SunNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guangyan Qing Qi Lu Xiuling Li Jing Liu Mingliang Ye Xinmiao Liang Taolei Sun Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
description	Capture of low-abundance multiply phosphorylated peptides (MPPs) is difficult due to limitation of enrichment materials and their interactions with phosphates. Here the authors show, a smart polymer driven by specific but tunable hydrogen bonding interactions can differentially complex with MPPs, singly phosphorylated and non-modified peptides.
format	article
author	Guangyan Qing Qi Lu Xiuling Li Jing Liu Mingliang Ye Xinmiao Liang Taolei Sun
author_facet	Guangyan Qing Qi Lu Xiuling Li Jing Liu Mingliang Ye Xinmiao Liang Taolei Sun
author_sort	Guangyan Qing
title	Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
title_short	Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
title_full	Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
title_fullStr	Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
title_full_unstemmed	Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
title_sort	hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f7b27a5d690045c6970c757ffb33811a
work_keys_str_mv	AT guangyanqing hydrogenbondbasedsmartpolymerforhighlyselectiveandtunablecaptureofmultiplyphosphorylatedpeptides AT qilu hydrogenbondbasedsmartpolymerforhighlyselectiveandtunablecaptureofmultiplyphosphorylatedpeptides AT xiulingli hydrogenbondbasedsmartpolymerforhighlyselectiveandtunablecaptureofmultiplyphosphorylatedpeptides AT jingliu hydrogenbondbasedsmartpolymerforhighlyselectiveandtunablecaptureofmultiplyphosphorylatedpeptides AT mingliangye hydrogenbondbasedsmartpolymerforhighlyselectiveandtunablecaptureofmultiplyphosphorylatedpeptides AT xinmiaoliang hydrogenbondbasedsmartpolymerforhighlyselectiveandtunablecaptureofmultiplyphosphorylatedpeptides AT taoleisun hydrogenbondbasedsmartpolymerforhighlyselectiveandtunablecaptureofmultiplyphosphorylatedpeptides
_version_	1718386328779882496

Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides

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