Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum

In the mammalian cerebellum, surplus synapses between climbing fibers (CF) and Purkinje cells (PC) are developmentally pruned. Here, Nakayama and colleagues show that ablation of microglia impairs pruning of CF-PC synapses because of dysfunction of GABAergic inhibition prerequisite for pruning.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hisako Nakayama, Manabu Abe, Chie Morimoto, Tadatsune Iida, Shigeo Okabe, Kenji Sakimura, Kouichi Hashimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7b66f5d077b4f0ea3babcd030736b66
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f7b66f5d077b4f0ea3babcd030736b66
record_format	dspace
spelling	oai:doaj.org-article:f7b66f5d077b4f0ea3babcd030736b662021-12-02T17:31:59ZMicroglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum10.1038/s41467-018-05100-z2041-1723https://doaj.org/article/f7b66f5d077b4f0ea3babcd030736b662018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05100-zhttps://doaj.org/toc/2041-1723In the mammalian cerebellum, surplus synapses between climbing fibers (CF) and Purkinje cells (PC) are developmentally pruned. Here, Nakayama and colleagues show that ablation of microglia impairs pruning of CF-PC synapses because of dysfunction of GABAergic inhibition prerequisite for pruning.Hisako NakayamaManabu AbeChie MorimotoTadatsune IidaShigeo OkabeKenji SakimuraKouichi HashimotoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hisako Nakayama Manabu Abe Chie Morimoto Tadatsune Iida Shigeo Okabe Kenji Sakimura Kouichi Hashimoto Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum
description	In the mammalian cerebellum, surplus synapses between climbing fibers (CF) and Purkinje cells (PC) are developmentally pruned. Here, Nakayama and colleagues show that ablation of microglia impairs pruning of CF-PC synapses because of dysfunction of GABAergic inhibition prerequisite for pruning.
format	article
author	Hisako Nakayama Manabu Abe Chie Morimoto Tadatsune Iida Shigeo Okabe Kenji Sakimura Kouichi Hashimoto
author_facet	Hisako Nakayama Manabu Abe Chie Morimoto Tadatsune Iida Shigeo Okabe Kenji Sakimura Kouichi Hashimoto
author_sort	Hisako Nakayama
title	Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum
title_short	Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum
title_full	Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum
title_fullStr	Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum
title_full_unstemmed	Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum
title_sort	microglia permit climbing fiber elimination by promoting gabaergic inhibition in the developing cerebellum
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f7b66f5d077b4f0ea3babcd030736b66
work_keys_str_mv	AT hisakonakayama microgliapermitclimbingfibereliminationbypromotinggabaergicinhibitioninthedevelopingcerebellum AT manabuabe microgliapermitclimbingfibereliminationbypromotinggabaergicinhibitioninthedevelopingcerebellum AT chiemorimoto microgliapermitclimbingfibereliminationbypromotinggabaergicinhibitioninthedevelopingcerebellum AT tadatsuneiida microgliapermitclimbingfibereliminationbypromotinggabaergicinhibitioninthedevelopingcerebellum AT shigeookabe microgliapermitclimbingfibereliminationbypromotinggabaergicinhibitioninthedevelopingcerebellum AT kenjisakimura microgliapermitclimbingfibereliminationbypromotinggabaergicinhibitioninthedevelopingcerebellum AT kouichihashimoto microgliapermitclimbingfibereliminationbypromotinggabaergicinhibitioninthedevelopingcerebellum
_version_	1718380467912179712

Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum

Ejemplares similares