Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour

Abstract Zhoushan cattle are an endangered cattle breed in the Zhoushan islands in China. Since Zhoushan cattle have been bred in isolation, they show unique characteristics, such as dark black coat colour. However, no studies have been conducted on the genome of Zhoushan cattle. Here, we performed...

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Autores principales:	Lihua Jiang, Tetsuo Kon, Chunyan Chen, Ryota Ichikawa, Qiyuan Zheng, Liyi Pei, Ikuyo Takemura, Lauden Hagai Nsobi, Hiromasa Tabata, Hao Pan, Yoshihiro Omori, Atsushi Ogura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f7b7ed123176489fab85c71397cf5d86
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spelling	oai:doaj.org-article:f7b7ed123176489fab85c71397cf5d862021-12-02T17:51:16ZWhole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour10.1038/s41598-021-96896-22045-2322https://doaj.org/article/f7b7ed123176489fab85c71397cf5d862021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96896-2https://doaj.org/toc/2045-2322Abstract Zhoushan cattle are an endangered cattle breed in the Zhoushan islands in China. Since Zhoushan cattle have been bred in isolation, they show unique characteristics, such as dark black coat colour. However, no studies have been conducted on the genome of Zhoushan cattle. Here, we performed whole-genome sequencing of seven individuals of Zhoushan cattle and nine cattle in Wenling, geographically close to the Zhoushan islands. By integrating our data and publicly-available data, we found that Zhoushan cattle are genetically highly similar to Bos indicus cattle in south-eastern China. Furthermore, by identifying the genomic regions shared between Zhoushan cattle and Angus cattle, a Bos taurus breed, we found that the p.F195L mutation in melanocyte-stimulating hormone receptor (MC1R) could be associated with their dark black coat colour. Taken together, our results provide a valuable resource for characterising the uniqueness of Zhoushan cattle.Lihua JiangTetsuo KonChunyan ChenRyota IchikawaQiyuan ZhengLiyi PeiIkuyo TakemuraLauden Hagai NsobiHiromasa TabataHao PanYoshihiro OmoriAtsushi OguraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lihua Jiang Tetsuo Kon Chunyan Chen Ryota Ichikawa Qiyuan Zheng Liyi Pei Ikuyo Takemura Lauden Hagai Nsobi Hiromasa Tabata Hao Pan Yoshihiro Omori Atsushi Ogura Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour
description	Abstract Zhoushan cattle are an endangered cattle breed in the Zhoushan islands in China. Since Zhoushan cattle have been bred in isolation, they show unique characteristics, such as dark black coat colour. However, no studies have been conducted on the genome of Zhoushan cattle. Here, we performed whole-genome sequencing of seven individuals of Zhoushan cattle and nine cattle in Wenling, geographically close to the Zhoushan islands. By integrating our data and publicly-available data, we found that Zhoushan cattle are genetically highly similar to Bos indicus cattle in south-eastern China. Furthermore, by identifying the genomic regions shared between Zhoushan cattle and Angus cattle, a Bos taurus breed, we found that the p.F195L mutation in melanocyte-stimulating hormone receptor (MC1R) could be associated with their dark black coat colour. Taken together, our results provide a valuable resource for characterising the uniqueness of Zhoushan cattle.
format	article
author	Lihua Jiang Tetsuo Kon Chunyan Chen Ryota Ichikawa Qiyuan Zheng Liyi Pei Ikuyo Takemura Lauden Hagai Nsobi Hiromasa Tabata Hao Pan Yoshihiro Omori Atsushi Ogura
author_facet	Lihua Jiang Tetsuo Kon Chunyan Chen Ryota Ichikawa Qiyuan Zheng Liyi Pei Ikuyo Takemura Lauden Hagai Nsobi Hiromasa Tabata Hao Pan Yoshihiro Omori Atsushi Ogura
author_sort	Lihua Jiang
title	Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour
title_short	Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour
title_full	Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour
title_fullStr	Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour
title_full_unstemmed	Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour
title_sort	whole-genome sequencing of endangered zhoushan cattle suggests its origin and the association of mc1r with black coat colour
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f7b7ed123176489fab85c71397cf5d86
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Whole-genome sequencing of endangered Zhoushan cattle suggests its origin and the association of MC1R with black coat colour

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