Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

The etiology of focal cortical dysplasia (FCD) is not fully understood. Here authors generate an mTORC1 overactivation mouse model that recapitulates hallmarks of type II FCDs, including spontaneous seizures, and suggest that neuronal defects, rather than macrostructural changes, lead to seizures.

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Autores principales:	Lawrence S. Hsieh, John H. Wen, Kumiko Claycomb, Yuegao Huang, Felicia A. Harrsch, Janice R. Naegele, Fahmeed Hyder, Gordon F. Buchanan, Angelique Bordey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7ba5ffa0e6d426fa4bef37c114838b1
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spelling	oai:doaj.org-article:f7ba5ffa0e6d426fa4bef37c114838b12021-12-02T15:34:10ZConvulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement10.1038/ncomms117532041-1723https://doaj.org/article/f7ba5ffa0e6d426fa4bef37c114838b12016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11753https://doaj.org/toc/2041-1723The etiology of focal cortical dysplasia (FCD) is not fully understood. Here authors generate an mTORC1 overactivation mouse model that recapitulates hallmarks of type II FCDs, including spontaneous seizures, and suggest that neuronal defects, rather than macrostructural changes, lead to seizures.Lawrence S. HsiehJohn H. WenKumiko ClaycombYuegao HuangFelicia A. HarrschJanice R. NaegeleFahmeed HyderGordon F. BuchananAngelique BordeyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lawrence S. Hsieh John H. Wen Kumiko Claycomb Yuegao Huang Felicia A. Harrsch Janice R. Naegele Fahmeed Hyder Gordon F. Buchanan Angelique Bordey Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement
description	The etiology of focal cortical dysplasia (FCD) is not fully understood. Here authors generate an mTORC1 overactivation mouse model that recapitulates hallmarks of type II FCDs, including spontaneous seizures, and suggest that neuronal defects, rather than macrostructural changes, lead to seizures.
format	article
author	Lawrence S. Hsieh John H. Wen Kumiko Claycomb Yuegao Huang Felicia A. Harrsch Janice R. Naegele Fahmeed Hyder Gordon F. Buchanan Angelique Bordey
author_facet	Lawrence S. Hsieh John H. Wen Kumiko Claycomb Yuegao Huang Felicia A. Harrsch Janice R. Naegele Fahmeed Hyder Gordon F. Buchanan Angelique Bordey
author_sort	Lawrence S. Hsieh
title	Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement
title_short	Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement
title_full	Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement
title_fullStr	Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement
title_full_unstemmed	Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement
title_sort	convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f7ba5ffa0e6d426fa4bef37c114838b1
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Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement

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