Extraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance

The One Health approach emphasizes the importance of antimicrobial resistance (AMR) as a major concern both in public health and in food animal production systems. As a general classification, <i>E. coli</i> can be distinguished based on the ability to cause infection of the gastrointest...

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Autores principales:	Valerio M. Sora, Gabriele Meroni, Piera A. Martino, Alessio Soggiu, Luigi Bonizzi, Alfonso Zecconi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Escherichia coli</i> ExPEC virulence factors antibiotic resistance Medicine R
Acceso en línea:	https://doaj.org/article/f7ba9a446e034a62a391e40e5e188d63
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spelling	oai:doaj.org-article:f7ba9a446e034a62a391e40e5e188d632021-11-25T18:37:32ZExtraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance10.3390/pathogens101113552076-0817https://doaj.org/article/f7ba9a446e034a62a391e40e5e188d632021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1355https://doaj.org/toc/2076-0817The One Health approach emphasizes the importance of antimicrobial resistance (AMR) as a major concern both in public health and in food animal production systems. As a general classification, <i>E. coli</i> can be distinguished based on the ability to cause infection of the gastrointestinal system (IPEC) or outside of it (ExPEC). Among the different pathogens, <i>E. coli</i> are becoming of great importance, and it has been suggested that ExPEC may harbor resistance genes that may be transferred to pathogenic or opportunistic bacteria. ExPEC strains are versatile bacteria that can cause urinary tract, bloodstream, prostate, and other infections at non-intestinal sites. In this context of rapidly increasing multidrug-resistance worldwide and a diminishingly effective antimicrobial arsenal to tackle resistant strains. ExPEC infections are now a serious public health threat worldwide. However, the clinical and economic impact of these infections and their optimal management are challenging, and consequently, there is an increasing awareness of the importance of ExPECs amongst healthcare professionals and the general public alike. This review aims to describe pathotype characteristics of ExPEC to increase our knowledge of these bacteria and, consequently, to increase our chances to control them and reduce the risk for AMR, following a One Health approach.Valerio M. SoraGabriele MeroniPiera A. MartinoAlessio SoggiuLuigi BonizziAlfonso ZecconiMDPI AGarticle<i>Escherichia coli</i>ExPECvirulence factorsantibiotic resistanceMedicineRENPathogens, Vol 10, Iss 1355, p 1355 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Escherichia coli</i> ExPEC virulence factors antibiotic resistance Medicine R
spellingShingle	<i>Escherichia coli</i> ExPEC virulence factors antibiotic resistance Medicine R Valerio M. Sora Gabriele Meroni Piera A. Martino Alessio Soggiu Luigi Bonizzi Alfonso Zecconi Extraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance
description	The One Health approach emphasizes the importance of antimicrobial resistance (AMR) as a major concern both in public health and in food animal production systems. As a general classification, <i>E. coli</i> can be distinguished based on the ability to cause infection of the gastrointestinal system (IPEC) or outside of it (ExPEC). Among the different pathogens, <i>E. coli</i> are becoming of great importance, and it has been suggested that ExPEC may harbor resistance genes that may be transferred to pathogenic or opportunistic bacteria. ExPEC strains are versatile bacteria that can cause urinary tract, bloodstream, prostate, and other infections at non-intestinal sites. In this context of rapidly increasing multidrug-resistance worldwide and a diminishingly effective antimicrobial arsenal to tackle resistant strains. ExPEC infections are now a serious public health threat worldwide. However, the clinical and economic impact of these infections and their optimal management are challenging, and consequently, there is an increasing awareness of the importance of ExPECs amongst healthcare professionals and the general public alike. This review aims to describe pathotype characteristics of ExPEC to increase our knowledge of these bacteria and, consequently, to increase our chances to control them and reduce the risk for AMR, following a One Health approach.
format	article
author	Valerio M. Sora Gabriele Meroni Piera A. Martino Alessio Soggiu Luigi Bonizzi Alfonso Zecconi
author_facet	Valerio M. Sora Gabriele Meroni Piera A. Martino Alessio Soggiu Luigi Bonizzi Alfonso Zecconi
author_sort	Valerio M. Sora
title	Extraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance
title_short	Extraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance
title_full	Extraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance
title_fullStr	Extraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance
title_full_unstemmed	Extraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance
title_sort	extraintestinal pathogenic <i>escherichia coli</i>: virulence factors and antibiotic resistance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f7ba9a446e034a62a391e40e5e188d63
work_keys_str_mv	AT valeriomsora extraintestinalpathogeniciescherichiacoliivirulencefactorsandantibioticresistance AT gabrielemeroni extraintestinalpathogeniciescherichiacoliivirulencefactorsandantibioticresistance AT pieraamartino extraintestinalpathogeniciescherichiacoliivirulencefactorsandantibioticresistance AT alessiosoggiu extraintestinalpathogeniciescherichiacoliivirulencefactorsandantibioticresistance AT luigibonizzi extraintestinalpathogeniciescherichiacoliivirulencefactorsandantibioticresistance AT alfonsozecconi extraintestinalpathogeniciescherichiacoliivirulencefactorsandantibioticresistance
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Extraintestinal Pathogenic <i>Escherichia coli</i>: Virulence Factors and Antibiotic Resistance

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